DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8036 and SPBC2G5.05

DIOPT Version :9

Sequence 1:	NP_649812.2	Gene:	CG8036 / 41027	FlyBaseID:	FBgn0037607	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_596066.1	Gene:	SPBC2G5.05 / 2540441	PomBaseID:	SPBC2G5.05	Length:	685	Species:	Schizosaccharomyces pombe

Alignment Length:	690	Identity:	191/690 - (27%)
Similarity:	294/690 - (42%)	Gaps:	102/690 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DLKDLA-QKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPSSDRFILSKGH 76
            |:..|| ..:|..:::.|..:|||||.:...:|....|||.:.::.|..||:..:.||||||.||
pombe     8 DIDTLAINTIRTLAVDTTAHAKSGHPGAPMGLAPAAHVLFSRIMKFNPAHPKWLNRDRFILSNGH 72

  Fly    77 AAPILYAAWAEAGL-FPIADLNNLRKIDSDLEGHP---TPRLNFIDVGTGSLGQGVAVGAGMAYV 137
            |..:.|......|. ..|.||...|::.|...|||   .|.|| |:.|.|.||||:|...|:| :
pombe    73 ACVLQYIMCHLLGYKLTIEDLKQFRQVGSKTPGHPETHNPDLN-IETGAGPLGQGIASAVGLA-I 135

  Fly   138 GK----------NFDKADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEAT 192
            ||          .||.....|:..:|||...||...|:...|||.||.||..::|.|::....||
pombe   136 GKAHSAAVYNKPGFDLFSNYTFCFLGDGCLQEGVSSEACSLAGHLKLSNLIAVWDNNKITIDGAT 200

  Fly   193 SLQHKLDVYRDRLEAFGFNAV-VVDGH-DVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIED 255
            |:....||.: |.||:|:|.| |.:|. |::.:.|.|..|....:|||.|..||..|.. ..::.
pombe   201 SMSFDEDVEK-RFEAYGWNIVRVANGDTDLDGIEKGFREAMSCTDKPTLINLKTTIGYG-SELQG 263

  Fly   256 LDNWHGKPLGDKAAEVVKHLEGLIVNKNVKLTP-------KPVPKTGAAPD-------------V 300
            ..:.||.||..:....||.|.|....|..::.|       :.|....:|.:             .
pombe   264 THSVHGSPLKPEDCVHVKKLFGFDPTKTFQVPPEVYAYYKERVAIASSAEEEYKKMYASYKQSYP 328

  Fly   301 DINN-----IKLSSP-------PAYKLGD-SIATRLAYGTALAKIGQNNLRVV-------ALDGD 345
            |::|     :....|       |.||.|| ::|||     .|::|..:.|..|       :.|..
pombe   329 DLSNQLERILSRKFPEGWEKHLPVYKPGDKAVATR-----KLSEIVLDALCPVLPELVGGSADLT 388

  Fly   346 TKNSTFSDKLKNLDPQ---------RYIECFIAEQNLVGVAVGAACRRRTVAFVSTFATFFTRAF 401
            ..|.|..:...:..|.         |||...|.|..:.|:..|.|.....:.:..||..|.:.|.
pombe   389 PSNLTRWEGAADFQPPSSKLGTYAGRYIRYGIREHGMAGIMNGLAVYGPIIPYGGTFLNFVSYAA 453

  Fly   402 DQIRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDAVSTERAVELAA 466
            ..:||.|::.:.|.:|.:|....:|||||:...:|..|.||.:|....:.|:|...|..|...|.
pombe   454 GAVRMAALNNSRVIYVATHDSIGLGEDGPTHQPIETFAHFRAMPNINCWRPADGNETSAAYYSAL 518

  Fly   467 NTKGV-CFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECLAAADQLEKNC 530
            .:... ..:..:|.|...:.::.....:..|.|:.:....::.|:|.|..:..|:.....||...
pombe   519 TSDSTPSILALTRQNLPQLENSTIENALKGGYVMLENKEADITLVGTGSEVSLCIDTVKTLETEY 583

  Fly   531 -ITVRVIDPFTVKPLDAELIIEHGKQCGGRVVVVEDHYQQGGLGEAVLS----ALAGERNFVVKH 590
             :..||:.      |....:.|...: ..|:.|:.|       |...:|    |..|.|.:|.:.
pombe   584 NLKARVVS------LPCWEVFEQQPE-SYRLSVIPD-------GIPAMSVEVWATNGWRRYVHEA 634

  Fly   591 LYVPTVPRSGPPSVLIDMF-----GIS--ARHVVNAVNEI 623
            ..:.|...|||...|.:.|     |::  |:..|:|..:|
pombe   635 FGMHTFGDSGPAPKLYEKFHFTTSGVAQRAKKTVDAYKDI 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8036	NP_649812.2	PRK05899	8..624	CDD:235639	191/690 (28%)
		TPP_TK	19..270	CDD:238970	94/266 (35%)
		TPP_PYR_DXS_TK_like	324..478	CDD:132916	41/170 (24%)
		Transketolase_C	496..616	CDD:280875	29/131 (22%)
SPBC2G5.05	NP_596066.1	TktA	5..669	CDD:223100	188/683 (28%)
		Transketolase_N	9..343	CDD:278863	106/337 (31%)
		Transket_pyr	358..536	CDD:280874	46/182 (25%)
		Transketolase_C	549..660	CDD:280875	27/124 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	130	1.000	Domainoid score	I1329
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I1138
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		otm47260
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1527
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.750