DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8032 and SMOX

DIOPT Version :9

Sequence 1:	NP_001262380.1	Gene:	CG8032 / 41026	FlyBaseID:	FBgn0037606	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001257620.1	Gene:	SMOX / 54498	HGNCID:	15862	Length:	585	Species:	Homo sapiens

Alignment Length:	593	Identity:	196/593 - (33%)
Similarity:	289/593 - (48%)	Gaps:	85/593 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SAGAGDQPQTSG--NNTNVKIVIIGAGMAGLSAANHLLQNGCDDFLILEARGRVGGRIVSIPLSN 86
            |..:.|.|.:.|  .....::|:||||:|||:||..||:.|..|..:|||...:|||:.|:.| .
Human     7 SGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKL-G 70

  Fly    87 NQKIELGANWIHGVLGNPIFELAVQHGL----------VSVVNVPKPHKVVA-TTEDGHQVPFNI 140
            :...||||.||||..||||:.||..:||          |..:::...:.|.. .|..|.::|.::
Human    71 HATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDV 135

  Fly   141 LQEIYEAYVCFLRRCDEYFLCQYSPPPDI---HSVGEHINYEIEIYLSGVQDPKE--KRLKQSIF 200
            ::|..:.|........|:|  ::..|.:.   :|||.....|:...:....|..|  ||||.::.
Human   136 VEEFSDLYNEVYNLTQEFF--RHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMI 198

  Fly   201 NCLLKRETCITGCNNMDEVDLLELGSYTELQGGNIVLPTGYSSILRPLGAQIAKQSILTKCPVKK 265
            ...||.|:|.:..::||||.|...|.:||:.|.:.::|:|:..::..|...|....|....||:.
Human   199 QQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRC 263

  Fly   266 IHWKRKKTFTGLETVDENSEDEHSDDSERTVTEVPTGEIRGASVESNTSSNCDY-PAGNVRIDCE 329
            |||.:.........::...|.:|:.|         ||| .|...|.......|. ...:|.::||
Human   264 IHWDQASARPRGPEIEPRGEGDHNHD---------TGE-GGQGGEEPRGGRWDEDEQWSVVVECE 318

  Fly   330 DGRVFHAAHVICTIPLGVLKNTHRTLFDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSADISE 394
            |..:..|.|||.|:.|||||..:.:.|.|.||..|..:|..|..||.||||||:|.||...:.:.
Human   319 DCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNS 383

  Fly   395 IMLLWDDDKRDMNSSEEELASEAYLSKNWFKKIYSFAKVTDTL---------LLGWVSGREAEYM 450
            :..:|:|        |.|..:..|..:.|::||..|    |.|         |.||:.|.||..|
Human   384 LQFVWED--------EAESHTLTYPPELWYRKICGF----DVLYPPERYGHVLSGWICGEEALVM 436

  Fly   451 EKLDHEAVAEKCTEILRNFLQDPYVPKPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIENLA--- 512
            ||.|.|||||.|||:||.|..:|.:|||:|.:.::|.|..:..|:|:...||::..|:|.||
Human   437 EKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPL 501

  Fly   513 ----------------------------QPLYATPQAMKP-AIVFAGEHTHSSFYSTVHGAYLSG 548
                                        |||.|...|:|| .::|:||.||..:|||.|||.|||
Human   502 PYTESSKTAHGSSTKQQPGHLFSSKCPEQPLDANRGAVKPMQVLFSGEATHRKYYSTTHGALLSG 566

  Fly   549 RTAAQHLL 556
            :..|..|:
Human   567 QREAARLI 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8032	NP_001262380.1	NAD_binding_8	44..104	CDD:290186	30/59 (51%)
CG8032	NP_001262380.1	Amino_oxidase	49..556	CDD:279874	186/564 (33%)
SMOX	NP_001257620.1	NAD_binding_8	<45..88	CDD:290186	19/43 (44%)
SMOX	NP_001257620.1	PLN02568	50..578	CDD:215308	179/550 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69268
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2780
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48501
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	1	1.000	-	-		otm42058
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.700