DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8032 and Su(var)3-3

DIOPT Version :9

Sequence 1:	NP_001262380.1	Gene:	CG8032 / 41026	FlyBaseID:	FBgn0037606	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster

Alignment Length:	603	Identity:	148/603 - (24%)
Similarity:	250/603 - (41%)	Gaps:	146/603 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KIVIIGAGMAGLSAANHLLQNGCDDFLILEARGRVGGRIVSIPLSNNQKIELGANWIHGVLGNPI 105
            |:::||||::||:.|:.|.|.|. |.::||||.|||||| |....|:...::||..:.||.|||:
  Fly   266 KVIVIGAGISGLAVAHQLQQFGM-DVIVLEARDRVGGRI-STFRKNSYIADVGAMVVTGVYGNPM 328

  Fly   106 FELAVQHG--LVSVVN-----------VPKPHKVVATTED----------GHQVPFNILQEIYEA 147
            ..|:.|.|  ||.:..           |||....|...|.          .|::.||...:
  Fly   329 TILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGD---- 389

  Fly   148 YVCFLRRCDEY-FLCQYSPPPDIHSVGEHINYEIEIYLSGVQDPKEKRLKQ-------------- 197
              |.:...|.. ::........:|..|:|:...|......::  :.:|||.
  Fly   390 --CPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIE--QRRRLKTLRDTIGKLKNEHLA 450

  Fly   198 ---------------------SIFNCLLKRETCITGCNNMDEVDLLELGSYTELQGG-------- 233
                                 :|.|..:|.|..|:..:::...:...|....||:..
  Fly   451 MINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLS 515

  Fly   234 ---NIVLPTGYSSILRPLGAQIAKQSILTKCPVKKIHWKRKKTFTGLETVDENSEDE---HSDDS 292
               .::|...::::      :.|..:.|....:|  ||            |::.:.|   |....
  Fly   516 SRDRLILDWHFANL------EFANATRLNNLSLK--HW------------DQDDDFEFIGHHTTV 560

  Fly   293 ERTVTEVPTGEIRGASVESNTS-SNCDYPAGNVRIDCEDGR------VFHAAHVICTIPLGVLK- 349
            ....:.||........:..|:: ....|....|.:..|:.:      .:.|..|:||:.|||||
  Fly   561 RNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKV 625

  Fly   350 --------NTHRTLFDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSADISEIMLLWDDDKRDM 406
                    .::...|||.||.:||::|:.|.||.::|:.|.::|.|           ||.:....
  Fly   626 AVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIF-----------WDPNANLF 679

  Fly   407 NSSEEELASEAYLSKNWFKKIYSFAKVTDT-LLLGWVSGREAEYMEKLDHEAVAEKCTEILRNFL 470
            .......||..        :::.|..::.: :||..|:|..|..:|.:..:.:..:|..:|:|..
  Fly   680 GHVGSTTASRG--------EMFLFWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIF 736

  Fly   471 QDPYVPKPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIENLAQPLYATPQAMK-----PAIVFAG 530
            .:..||:||..|.|.|:|..:..|:|:.:.||::..|.:.||.|:  .|.:.|     |.:.|||
  Fly   737 GNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPV--IPPSSKDAEGLPRLFFAG 799

  Fly   531 EHTHSSFYSTVHGAYLSG 548
            |||..::.:|||||||||
  Fly   800 EHTIRNYPATVHGAYLSG 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8032	NP_001262380.1	NAD_binding_8	44..104	CDD:290186	28/59 (47%)
CG8032	NP_001262380.1	Amino_oxidase	49..556	CDD:279874	143/595 (24%)
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311
		NAD_binding_8	269..327	CDD:290186	28/59 (47%)
		Amino_oxidase	274..824	CDD:279874	143/595 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46708
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.970