DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8032 and KDM1A

DIOPT Version :9

Sequence 1:	NP_001262380.1	Gene:	CG8032 / 41026	FlyBaseID:	FBgn0037606	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_006710537.1	Gene:	KDM1A / 23028	HGNCID:	29079	Length:	878	Species:	Homo sapiens

Alignment Length:	620	Identity:	157/620 - (25%)
Similarity:	241/620 - (38%)	Gaps:	168/620 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KIVIIGAGMAGLSAANHLLQNGCDDFLILEARGRVGGRIVSIPLSNNQKIELGANWIHGVLGNPI 105
            |::|||:|::||:||..|...|. |..:||||.|||||:.:. ...|...:|||..:.|:.|||:
Human   300 KVIIIGSGVSGLAAARQLQSFGM-DVTLLEARDRVGGRVATF-RKGNYVADLGAMVVTGLGGNPM 362

  Fly   106 FELAVQHGLVSVVN-------------------VPKP----------HKVVATTEDGHQVPFNIL 141
            ..::.|      ||                   |||.          ..:.||:...||:.||:|
Human   363 AVVSKQ------VNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVL 421

  Fly   142 Q----EIYEAYVCFLRRCDEYFLCQYSPPPDIHSVGEHINY---------EIEIYLSGVQDPKE- 192
            .    .:.:|....::..::            |...|.|.:         |::..|:.:.:.||
Human   422 NNKPVSLGQALEVVIQLQEK------------HVKDEQIEHWKKIVKTQEELKELLNKMVNLKEK 474

  Fly   193 -KRLKQSI---------------FNCLLKRETCITGCNNMDEVDLLELGSYTELQG--------- 232
             |.|.|..               |....|.......|...||:        .|.||
Human   475 IKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDEL--------AETQGKLEEKLQEL 531

  Fly   233 -GNIVLPTGYSS--ILRPLGAQI-----AKQSILTKCPVKKI---HWKRKKTFTGLETVDENSED 286
             .|...|..:.|  .|.....||     |........|:..:   ||             :..:|
Human   532 EANPPSPLFFCSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHW-------------DQDDD 583

  Fly   287 EHSDDSERTVTE----VPTGEIRGASVESN--------TSSNCDYPAGNVRIDCEDGRVFHAAHV 339
            .....|..||..    ||.....|..::.|        |:|.|:..|.|.| ......::....|
Human   584 FEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAV 647

  Fly   340 ICTIPLGVLKNTHRTL-FDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSADISEIMLLWDDDK 403
            :||:||||||.....: |.|.||::|..:::.:.||.::|:.|.::|.|           ||...
Human   648 LCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVF-----------WDPSV 701

  Fly   404 RDMNSSEEELAS--EAYLSKNWFKKIYSFAKVTDTLLLGWVSGREAEYMEKLDHEAVAEKCTEIL 466
            ..........||  |.:|..|.:|.         .:||..|:|..|..||.:..:.:..:|..||
Human   702 NLFGHVGSTTASRGELFLFWNLYKA---------PILLALVAGEAAGIMENISDDVIVGRCLAIL 757

  Fly   467 RNFLQDPYVPKPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIENLAQPLY------ATPQAMKPA 525
            :.......||:||..|.:.|::..:..|:|:.:..|::..|.:.:|||:.      ..||.: |.
Human   758 KGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPI-PR 821

  Fly   526 IVFAGEHTHSSFYSTVHGAYLS-----GRTAAQHL 555
            :.||||||..::.:|||||.||     ||.|.|.|
Human   822 LFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8032	NP_001262380.1	NAD_binding_8	44..104	CDD:290186	26/59 (44%)
CG8032	NP_001262380.1	Amino_oxidase	49..556	CDD:279874	152/612 (25%)
KDM1A	XP_006710537.1	SWIRM	197..284	CDD:282311
		NAD_binding_8	303..361	CDD:290186	26/59 (44%)
		Amino_oxidase	308..851	CDD:279874	148/605 (24%)
		SurA_N_3	<395..491	CDD:304439	18/107 (17%)
		NAT_SF	<441..>549	CDD:302625	22/127 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840