Protein Alignment CG8032 and KDM1B

DIOPT Version :10

• Sequence 1: NP_649811.1
• Gene: CG8032 / 41026
• FlyBaseID: FBgn0037606
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001426046.1
• Gene: KDM1B / 221656
• HGNCID: 21577
• Length: 832
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 135/568 - (23%)
• Similarity: 222/568 - (39%)
• Gaps: 127/568 - (22%)

  Fly    15 TEEGMANIG--SAGAGDQPQTSGNNTNVKIVIIGAGMAGLSAANHLLQNGCDDFLILEARGRVGG 77
            |.:|:.|.|  |.|| ||.....:..|..::|||||.|||:||..|...|. ...:|||:.|:||
Human   366 TRKGLINTGVLSVGA-DQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGI-KVTVLEAKDRIGG 428

  Fly    78 RIVSIPLSNNQKIELGANWIHGVLGNPIFELAVQHGLVSVVNVPKPHKVVATTEDGHQVP----- 137
            |:..........:..||..::|.:.||:..:..|.|    :::.|..:.....::|.::.
Human   429 RVWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLG----ISMHKFGERCDLIQEGGRITDPTID 489

  Fly   138 ------FNILQEIYEAYVCFLRRCDEYFLCQYSPPPDIHSVGEHIN--YEIEIYLSGVQDPKEKR 194
                  ||.|.::...:     |.|:   .|....|    :||.|.  |:..|..||:|   ...
Human   490 KRMDFHFNALLDVVSEW-----RKDK---TQLQDVP----LGEKIEEIYKAFIKESGIQ---FSE 539

  Fly   195 LKQSIFNCLLKRETCITGCNNMDEV-----DLLELGSYTELQGGNIVLPTGYSSILRPL--GAQI 252
            |:..:....|.......| :|:.:|     |..|.  :.:..|.:.:|..|||.|:..|  |..|
Human   540 LEGQVLQFHLSNLEYACG-SNLHQVSARSWDHNEF--FAQFAGDHTLLTPGYSVIIEKLAEGLDI 601

  Fly   253 AKQSILTKCPVKKIHWKRKKTFTGLETVDENSEDEHSDDSERTVTEVPTGEIRGASVESNTSSNC 317
            ..:|...:|                                                       .
Human   602 QLKSPQVQC-------------------------------------------------------I 611

  Fly   318 DYPAGNVRIDCEDGRVFHAAHVICTIPLGVLKNTHRTLFDPVLPQYKQESIENLMFGTVDKIFLE 382
            ||....|::...||..:.|..|:.|:||.:|:. ....|:|.|.:.|.::|.:|..|.::||.|:
Human   612 DYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQK-GAIQFNPPLSEKKMKAINSLGAGIIEKIALQ 675

  Fly   383 YERPFLSADISEIMLLWDDDKR--DMNSSEEELASEAYLSKNWFKKIYSF-AKVTDTLLLGWVSG 444
            :...|           ||...:  |........||:    :..|...|.. .:...::|:..::|
Human   676 FPYRF-----------WDSKVQGADFFGHVPPSASK----RGLFAVFYDMDPQKKHSVLMSVIAG 725

  Fly   445 REAEYMEKLDHEAVAEKCTEILRNFLQDPYVPKPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIE 509
            .....:..||.:.|.::|...||...::..||.|.:...|.|.:..:...||:.:..|.:.|..:
Human   726 EAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 790

  Fly   510 NLAQPLYATPQAMKPAIVFAGEHTHSSFYSTVHGAYLSGRTAAQHLLA 557
            .:|:.:..|       :.||||.|:..|..||.||||||...|..:.|
Human   791 IIAEDIQGT-------VFFAGEATNRHFPQTVTGAYLSGVREASKIAA 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8032	NP_649811.1	Amino_oxidase	49..556	CDD:396255	119/529 (22%)
KDM1B	NP_001426046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	282..301
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	447..476		6/32 (19%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	496..507		3/15 (20%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	547..581		7/36 (19%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	573..575		0/3 (0%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	808..824		9/15 (60%)