DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8032 and Paox

DIOPT Version :9

Sequence 1:	NP_001262380.1	Gene:	CG8032 / 41026	FlyBaseID:	FBgn0037606	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_722478.2	Gene:	Paox / 212503	MGIID:	1916983	Length:	504	Species:	Mus musculus

Alignment Length:	536	Identity:	174/536 - (32%)
Similarity:	266/536 - (49%)	Gaps:	70/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KIVIIGAGMAGLSAANHLLQNGCDDFL-ILEARGRVGGRIVSIPLSNNQKIELGANWIHG-VLGN 103
            :::::|:|:|||.||..|..:.....| :|||....||||.|...... .:||||:|||| ...|
Mouse     7 RVLVVGSGIAGLGAAQKLCSHRAAPHLRVLEATASAGGRIRSERCFGG-VVELGAHWIHGPSQDN 70

  Fly   104 PIFELAVQHGLVSVVNVPKPHKVVAT-----------TEDGHQVPFNILQEIYEAYVCFLRRCDE 157
            |:|:||.:.||:....:.:.:::|.|           :..|..|...::.|:...:...:.|..|
Mouse    71 PVFQLAAEFGLLGEKELSEENQLVDTGGHVALPSMIWSSSGTSVSLELMTEMARLFYGLIERTRE 135

  Fly   158 YFLCQYSPPPDIHSVGEHINYEI-EIYLSGVQDPKE-KRLKQSIFNCLLKRETCITGCNNMDEVD 220
             ||.:...|  :.||||.:..|| :...|..:|.:: ::.|.:|.|.....|.|::|.::||.|.
Mouse   136 -FLNESETP--MASVGEFLKKEISQQVASWTEDDEDTRKRKLAILNTFFNIECCVSGTHSMDLVA 197

  Fly   221 LLELGSYTELQGGNIVLPTGYSSILRPLGAQIAKQSILTKCPVKKIHWKRKKTFTGLETVDENSE 285
            |...|.||.|.|.:.:|..||..:...:.|.:.|.::....|||.|||
Mouse   198 LAPFGEYTVLPGLDCILAGGYQGLTDRILASLPKDTVAFDKPVKTIHW----------------- 245

  Fly   286 DEHSDDSERTVTEVPTGEIRGASVESNTSSNCDYPAGNVRIDCEDGRVFHAAHVICTIPLGVLKN 350
                           .|..:.|:....|     :|   |.::||||....|.|||.|:|||.||.
Mouse   246 ---------------NGSFQEAAFPGET-----FP---VLVECEDGARLPAHHVIVTVPLGFLKE 287

  Fly   351 THRTLFDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSADISEIMLLWDDDKRDMNSSEEELAS 415
            ...|.|:|.||..|.|:|:.|.|||.:|||||:|.||...|...|.::|:|     .|..::.|.
Mouse   288 HQDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWED-----TSPLQDTAL 347

  Fly   416 EAYLSKNWFKKIYSF----AKVTDTLLLGWVSGREAEYMEKLDHEAVAEKCTEILRNFLQDPYVP 476
            .  |...||||:..|    :..:..:|.|:::|.|:|:||.|..|.|....|::||....:|.:|
Mouse   348 S--LQDTWFKKLIGFLVQPSFESSHVLCGFIAGLESEFMETLSDEEVLLSLTQVLRRVTGNPQLP 410

  Fly   477 KPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIENLAQPLYATPQAMKPAIVFAGEHTHSSFYSTV 541
            ..|....:.|.|..:|.|:|:.:.||:|.:|::.:||||.......:..::||||.||.:||||.
Mouse   411 AAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLPEDGTGTQLQVLFAGEATHRTFYSTT 475

  Fly   542 HGAYLSGRTAAQHLLA 557
            |||.|||...|..|::
Mouse   476 HGALLSGWREADRLVS 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8032	NP_001262380.1	NAD_binding_8	44..104	CDD:290186	25/61 (41%)
CG8032	NP_001262380.1	Amino_oxidase	49..556	CDD:279874	171/525 (33%)
Paox	NP_722478.2	PLN02568	6..490	CDD:215308	173/533 (32%)
		NAD_binding_8	10..79	CDD:290186	30/69 (43%)
		Microbody targeting signal. /evidence=ECO:0000255	502..504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839611
Domainoid	1	1.000	240	1.000	Domainoid score	I2261
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2773
Isobase	1	0.950	-	0	Normalized mean entropy	S4267
OMA	1	1.010	-	-		QHG48501
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	1	1.000	-	-		otm44113
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	1	1.100	-	-	LDO	PTHR10742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750