DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8032 and hpo-15

DIOPT Version :9

Sequence 1:	NP_001262380.1	Gene:	CG8032 / 41026	FlyBaseID:	FBgn0037606	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_504456.1	Gene:	hpo-15 / 178934	WormBaseID:	WBGene00016061	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	133/558 - (23%)
Similarity:	239/558 - (42%)	Gaps:	126/558 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QPQTSGNNTNVK--IVIIGAGMAGLSAANHLLQNGCDDFLILEARGRVGGRIVSIPLSNNQKIEL 92
            |.::...::::|  |.|:|||::|||.|..|::.|.|||.|.|...|:||||.:||..:. .:::
Worm    20 QKESEKGDSSIKPSIAIVGAGISGLSTARRLIELGIDDFDIYEGLDRIGGRIHAIPYKDG-FLQM 83

  Fly    93 GANWIHGVLGNPIFELAVQHGLVSVVNVPKPHKVVATTEDGHQVPFNILQEIYEAYVCFLRRCDE 157
            ||.:|:|. .||::::|.:.||::.|.....|...|....|:|   |:.::..:.::.|..:.|
Worm    84 GAQFINGA-QNPLYKIANRLGLLADVVSDTAHVDNAHFAFGNQ---NVQEKDIKTFLDFTSKLD- 143

  Fly   158 YFLCQYSPPPDIHSVGEHINYEIEIYLSGVQDPKEKRLKQSIFNCLLKRETCITGCNNMDEVDLL 222
                     |...|:.:|               .||..::..|..:.          .:|.:..|
Worm   144 ---------PKYRSIAKH---------------DEKTARRYTFKEIF----------TLDYMHFL 174

  Fly   223 ELGSYTELQGGNIVLPTGYSSILRPLGAQ-----IAKQSILTKCPVKKIHWKRKKTFTGLETVDE 282
            :..::|: |..|:     :.|:.|...:.     .|..|.|:...:|:  |
Worm   175 KSQNFTD-QQTNV-----FDSLARSFRSYWEFEWAADWSTLSVHVLKE--W-------------- 217

  Fly   283 NSEDEHSDDSERTVTE--------------VP------TGEIRGASVESNTSSNCDYPAGNVRID 327
               :::..:.|...|.              :|      ...:...:::|||        |.:::.
Worm   218 ---NDYGPECESFATNKIGFKAILDDIAAPIPRKAFNFNSRVENINLDSNT--------GKIKLT 271

  Fly   328 CEDGRV-FHAAHVICTIPLGVLKNTHRTLFDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSAD 391
            ..|..| ....::|.|..|||||..|..:|.|.||:.|.|:||.:.||...|:|.|:|.||.|.:
Worm   272 VSDRAVPTEYDYIIVTSSLGVLKKYHHKMFTPPLPRQKIEAIEKIGFGGSCKVFFEWETPFWSNN 336

  Fly   392 ISEIMLL----WDDDKRDMNSSEEELASEAYLSKNWFKKIYSFAKVTDTLLLGWVSGREAEYMEK 452
            ...|..|    ...||.|....|..:....    :|...:.|          .|.:||..:.::.
Worm   337 TYSIAPLPVKGMIRDKLDAFEDETTILQVV----DWAPNVLS----------AWYAGRGHQLVDN 387

  Fly   453 LDHEAVAEKCTEILRNFLQDPYVPKPKRCVCTSWKSQDFTGGAYTSIPVGATQ-EDIENLAQPLY 516
            :..|.:.::.|:::|:...|..:|:|.:.:.|.....:...|:|:.:    || :.:.:::....
Worm   388 MSEEELKQRITKLMRDMYNDKSIPEPSKIIRTQLTKNELLLGSYSYM----TQVQALSHISHSQL 448

  Fly   517 ATPQAM--KPAIVFAGEHTHSSFYSTVHGAYLSGRTAA 552
            |.|..:  :|.::||||.||...:.|..|.|||||..|
Worm   449 AIPVKLEGRPKVLFAGEATHHRLFQTTIGGYLSGRREA 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8032	NP_001262380.1	NAD_binding_8	44..104	CDD:290186	26/59 (44%)
CG8032	NP_001262380.1	Amino_oxidase	49..556	CDD:279874	126/537 (23%)
hpo-15	NP_504456.1	Amino_oxidase	41..488	CDD:366721	126/537 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I2667
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2841
Isobase	1	0.950	-	0	Normalized mean entropy	S4267
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	1	1.100	-	-	LDO	PTHR10742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.850