DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8032 and kdm1b

DIOPT Version :9

Sequence 1:	NP_001262380.1	Gene:	CG8032 / 41026	FlyBaseID:	FBgn0037606	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_002932724.1	Gene:	kdm1b / 100489838	XenbaseID:	XB-GENE-982183	Length:	821	Species:	Xenopus tropicalis

Alignment Length:	584	Identity:	134/584 - (22%)
Similarity:	228/584 - (39%)	Gaps:	158/584 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TEEGMANIG----SAGAGDQPQTSGNNTNVKIVIIGAGMAGLSAANHLLQNGCDDFLILEARGRV 75
            :.:|:.|.|    |.|....|:...|.:   :::||||.|||:||..|...|. ...::|||.|:
Frog   356 SRKGLVNTGVLSVSPGQYLLPKEYHNKS---VIVIGAGPAGLAAARQLHNFGI-KVTVVEARDRI 416

  Fly    76 GGRIVSIPLSNNQKIELGANWIHGVLGNPIFELAVQHGLVSVVNVPKPHKVVATTEDGHQVP--- 137
            |||:..........:..||..::|.:.|||..:..|.|    :.:.|..:.....|:|.::.
Frog   417 GGRVWDEKSFKGVIVGKGAQIVNGCINNPIAIMCEQIG----IKMRKLREKCDLIEEGGRLTDPA 477

  Fly   138 --------FNILQEIYEAYVCFLRRCDEYFLCQYSPPPDIHSVGEHINYEIEIYL--SGVQ--DP 190
                    ||.:.::...:     |.|:   .|....|    :|:.|....:.:.  ||:|  |.
Frog   478 IDKRMDFHFNAVLDVVAEW-----RKDK---TQNQDAP----LGDKIQEICKAFTQESGIQFTDV 530

  Fly   191 KEKRLKQSIFNCLLKRETCITGCNNMDEV-----DLLELGSYTELQGGNIVLPTGYSSILRPLGA 250
            :||.|:..:.|.   ...|   .:|:.:|     |..|.  :.:..|.:.:|..|||.:
Frog   531 EEKVLQFHLGNL---EYAC---GSNLHKVSARSWDHNEF--FAQFAGDHTMLGAGYSMV------ 581

  Fly   251 QIAKQSILTKCPVKKIHWKRKKTFTGLETVDENSEDEHSDDSERTVTEVPTGEIRGASVESNTS- 314
                                         :|:.:|                    |..:..||.
Frog   582 -----------------------------IDKLAE--------------------GLDIRLNTPI 597

  Fly   315 SNCDYPAGNVRIDCEDGRVFHAAHVICTIPLGVLKNTHRTLFDPVLPQYKQESIENLMFGTVDKI 379
            .|.||.:..|||...||:.|.|...:.|:||.:|:. ....|:|:||:.|.::|.:|..|.::||
Frog   598 RNVDYTSQEVRITAADGQTFTAQKALVTVPLALLQK-GAIQFNPLLPEKKVKAIHSLGAGVIEKI 661

  Fly   380 FLEYERPFLSADISEIMLLWDD---------------DKRDMNSSEEELASEAYLSKNWFKKIYS 429
            .|::...|           ||:               :||.:.....::..|.
Frog   662 ALQFPYRF-----------WDNKIQGADFFGHIPPNCNKRGLFGVFYDMDPEG------------ 703

  Fly   430 FAKVTDTLLLGWVSGREAEYMEKLDHEAVAEKCTEILRNFLQDPYVPKPKRCVCTSWKSQDFTGG 494
                ...:|:..::|.....:::|:.:.|.::|..|||...::..||.|.:...|.|....:...
Frog   704 ----KHAVLMSVITGDAVTSIQELEDKQVVKQCMVILREVFKEQEVPAPIKYFVTHWAKDPWAHM 764

  Fly   495 AYTSIPVGATQEDIENLAQPLYATPQAMKPAIVFAGEHTHSSFYSTVHGAYLSGRTAAQHLLAS 558
            ||:.:..|.:.|..:.||:.:       :..|.||||.|:..|..||.||||||...|..:..|
Frog   765 AYSFVKTGGSGEAYDILAEDI-------QGKIFFAGEATNRHFPQTVSGAYLSGVREASKITTS 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8032	NP_001262380.1	NAD_binding_8	44..104	CDD:290186	21/59 (36%)
CG8032	NP_001262380.1	Amino_oxidase	49..556	CDD:279874	122/542 (23%)
kdm1b	XP_002932724.1	zf-CW	138..191	CDD:369393
kdm1b	XP_002932724.1	PLN02328	<301..818	CDD:215187	133/579 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940