DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p and TECPR2

DIOPT Version :9

Sequence 1:	NP_001303455.1	Gene:	p / 41025	FlyBaseID:	FBgn0086679	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_055659.2	Gene:	TECPR2 / 9895	HGNCID:	19957	Length:	1411	Species:	Homo sapiens

Alignment Length:	665	Identity:	152/665 - (22%)
Similarity:	244/665 - (36%)	Gaps:	169/665 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TCFDISDSYIIFGASSGSLYLF----NRNGKFLLLIPNKHGAITSLSI----SANSKYVAFATQR 86
            |..|.:..||..|:|.|.|||:    |:..|:     |..|...|:::    |.....||..|..
Human    39 TALDTNGDYIAVGSSIGMLYLYCRHLNQMRKY-----NFEGKTESITVVKLLSCFDDLVAAGTAS 98

  Fly    87 SLICVYAVNLSAQATPQVI----FTHLDQSVQVTCIHWTQDEKQFYYGDSRGQVSLVLLSSFIGH 147
            ..:.|:.:..|.....:.:    .|.:.:: .:|.:.|:.:..:.:.||.:|::  |..|..:..
Human    99 GRVAVFQLVSSLPGRNKQLRRFDVTGIHKN-SITALAWSPNGMKLFSGDDKGKI--VYSSLDLDQ 160

  Fly   148 SLLFNMTVHPLLYLDSP--IVQIDDFEYLLLVSNCTKCILCNTEYEDYKQIGNRPR--DGAFGAC 208
            .|     .:..|.|:.|  |||:|..:.:||||...:.:|..||.:..:|||.:||  .|.||||
Human   161 GL-----CNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGAC 220

  Fly   209 FF--VSPQESLQPSRIYCARPGSRVWEVDFEGEVIQTHQFKTALA--TAP----ARIQRPGSGTD 265
            |.  :..|..|   .:|.:|||.|:|:.|..|.|..|...|.|.|  ..|    .|::.|.||:.
Human   221 FIPGLCKQSDL---TLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSC 282

  Fly   266 ELDANAELLDYQPQNLQFAKVQRLNDDFLLAFTELGLYIFDIRRSAVVLWSNQFERIADCRSSGS 330
            .|          |:...........:.::|::.|..:|:.|....|.|........|.....:.:
Human   283 SL----------PERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTEN 337

  Fly   331 EIFVFTQSGALYSVQLQTLQSHAVSLIQQS-KLLPCANLLRQHVRYFADKAREDYELKQLNPLKQ 394
            |||..  .|....:::.:......|.::.. ::..|:.  |.||
Human   338 EIFFL--KGDRNIIRISSRPEGLTSTVRDGLEMSGCSE--RVHV--------------------- 377

  Fly   395 LLIERQEYELLNDISVIFDAITQCTGSALDTHSSGGSSATTERSLSGGSSSRAPPKGVYVLENAF 459
                 |:.|.|...:|   :.|:..||     |...|.|:..||.|...:|.....|:
Human   378 -----QQAEKLPGATV---SETRLRGS-----SMASSVASEPRSRSSSLNSTDSGSGL------- 422

  Fly   460 CDNLKQPLKTGHFKDALLTVTGKFGKNI--IKYKFNIFAEE--QQQLVRELIPASERSLPFKDIK 520
                   |..|      |..|.:.||..  :..:||..:.|  .|:||.:.|....     |..|
Human   423 -------LPPG------LQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKR-----KKKK 469

  Fly   521 ARYESGSEDQEEEIVRRCKKPAPQVPHISPEEKTLYNLYLIAKSAKFSRTQCVDRYRAVFDEYAA 585
            .:.|.||.......:.  ..|..:.|..||:.   .|..|::.::.                 ..
Human   470 KKTEGGSRSTCHSSLE--STPCSEFPGDSPQS---LNTDLLSMTSS-----------------VL 512

  Fly   586 GELVNLLEKLAQVMVEHGDTPDQ-----------AQRNCYEMYFDYLD-----PEMIWEVDDATR 634
            |..|:.|.         .::|||           .|.|.....|:.|:     |:.:.|.||...
Human   513 GSSVDQLS---------AESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDSLAEEDDIRT 568

  Fly   635 D----HIAAGFVLLN 645
            :    |.|.|..|||
Human   569 EMPHCHHAHGRELLN 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p	NP_001303455.1	WD40	<17..>132	CDD:225201	25/113 (22%)
		WD40	<21..128	CDD:295369	24/109 (22%)
		WD40 repeat	25..63	CDD:293791	12/36 (33%)
		WD40 repeat	68..107	CDD:293791	7/46 (15%)
		WD40 repeat	116..154	CDD:293791	8/37 (22%)
		WD40 repeat	161..196	CDD:293791	13/36 (36%)
		WD40 repeat	204..245	CDD:293791	17/42 (40%)
TECPR2	NP_055659.2	WD 1	23..66		10/26 (38%)
		WD40	36..365	CDD:225201	89/353 (25%)
		WD40 repeat	37..73	CDD:293791	13/38 (34%)
		WD 2	67..114		10/51 (20%)
		WD40 repeat	79..121	CDD:293791	6/41 (15%)
		WD 3	115..161		8/48 (17%)
		WD40 repeat	130..168	CDD:293791	8/44 (18%)
		WD 4	162..203		15/45 (33%)
		WD40 repeat	175..197	CDD:293791	9/21 (43%)
		WD 5	204..265		26/63 (41%)
		WD40 repeat	215..256	CDD:293791	18/43 (42%)
		WD 6	266..309		9/52 (17%)
		WD40 repeat	278..324	CDD:293791	10/55 (18%)
		WD 7	310..343		8/34 (24%)
		WD40 repeat	329..351	CDD:293791	5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..439		20/87 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..542		18/114 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..637		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..779
		TECPR 1	945..976
		Hyd_WA	947..973	CDD:283993
		TECPR 2	994..1027
		Hyd_WA	996..1026	CDD:283993
		TECPR 3	1179..1209
		Hyd_WA	1181..1206	CDD:283993
		TECPR 4	1226..1259
		TECPR 5	1279..1310
		Hyd_WA	1281..1309	CDD:283993
		TECPR 6	1322..1353
		Hyd_WA	1324..1352	CDD:283993
		TECPR	1347..1379	CDD:214782
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1388..1411
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840