DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p and CG11141

DIOPT Version :9

Sequence 1:	NP_001303455.1	Gene:	p / 41025	FlyBaseID:	FBgn0086679	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001286159.1	Gene:	CG11141 / 35672	FlyBaseID:	FBgn0033177	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	162/738 - (21%)
Similarity:	265/738 - (35%)	Gaps:	176/738 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IKYTCFDISDSYIIFGASSGSLYLFNRN-GKFLLLIPNKHGAITSLSISANSKY-VAFATQRSLI 89
            :..||.|.::.::..|:.:|.::.:||: |:...|.......||.:.:..:.:| ||.......:
  Fly    36 LNLTCVDATEEFLAMGSDAGIVFWYNRHTGEMQKLKAEVATRITCVRVVNSVEYMVAAGCANGQV 100

  Fly    90 CVYAV--------NLSAQAT---PQVIFTHLD-QSVQVTCIHWTQDEKQFYYGDSRGQVSLVLLS 142
            .::.:        :|.|..|   |...:|..| ....|:|..|:::..:.|.||.:|.|.|..|
  Fly   101 SIFQIQKELPRDLDLVAPCTKSRPIERYTIRDLHKCVVSCCEWSKNGMKLYSGDRQGVVVLTEL- 164

  Fly   143 SFIGHSLLFNMTVHPLLYLDSPIVQIDDFEYLLLVSNCTKCILC----NTEYEDYKQIGNRPRDG 203
            .:..|   .:.:|. :|.....|||:...:..|||:...:||:|    .|...:..|:|.:.|..
  Fly   165 DYQAH---LSKSVE-ILSEAYEIVQLSVRQSYLLVATLYRCIVCQMDAQTSQWNITQVGKKDRKQ 225

  Fly   204 AF--GACFFVSPQESLQPSRIYCARPGSRVWEVDFEGEVIQTHQFKTALATAPA--------RIQ 258
            ..  || .|:..||:.:| ::.|.|||.|.|..|..|.|.:|..|:.|:..:|.        :.:
  Fly   226 LIDCGA-IFLKKQEANKP-QLVCGRPGLRFWVADAAGNVSKTVIFRDAVLRSPTWEIPILNPKQR 288

  Fly   259 RPGSGTDELDANAE------LLDYQPQNLQFAKVQRL-----NDDFLLAFTELGLYIFDIRRSAV 312
            ...|||....|:..      |.|.....:..:..::|     :|..|:...:..||:.::.|..|
  Fly   289 SEPSGTHHTSASTSSTRHSGLADGDVGYVASSNFRQLYLYDGHDSLLVTHDDATLYVLNLDRLKV 353

  Fly   313 VLWSNQFERIADCRSSGSEIFVFTQSGALYSV-QLQTLQSHAVSLIQQSKLLPCANLLRQHVRYF 376
            ...:....:|.|....|.||||...:..|..: .|....:....:|....:.|...:|..|:...
  Fly   354 EAVARGLRKILDFCVCGKEIFVLEGNRTLLRLAPLPEPPNKTAKVIFNPLMPPPVPVLGSHLSQL 418

  Fly   377 -----------ADKAREDYEL---KQLN-----------PLKQLLIERQEYELLNDISVIFDAIT 416
                       ...|.|.:||   :|||           ||.|   :.:..|:...|
  Fly   419 ESPIELQAEPVLQNAEECFELSPVEQLNLNVPIEIAVESPLTQ---QNRRLEIFRRI-------- 472

  Fly   417 QCTGSALDTHSSGGSSATTERSLSGGSSSRAPPKGVY------------------VLENAFC--- 460
                ..:|...   |...|.|..|.|....|...|:.                  ::|.::|
  Fly   473 ----GEMDFEQ---SIVHTTRKTSVGKPPEASGVGIVEIGHETHELRLPLTNAATLMEASYCQME 530

  Fly   461 -DNLKQPLK-----TGHFKDALLTVTGKFGKNIIKYKFNIFAEEQQQLVRELIPASERSLPFKDI 519
             :.|..||.     ..|..|||...|  ..|.:        ||:.:.|..||           |:
  Fly   531 NNGLASPLDMKAAFLQHLPDALSPTT--LQKTV--------AEKAKTLAAEL-----------DL 574

  Fly   520 KARYESGSEDQEEEIVRRCKKPAPQVPHISPEEKTLYNLYLIAKSAKFSRTQCVDRYRAV--FDE 582
            ...:.:....:|...|:      .|.|.||......|..:|...|.:.|     .|..|.  .|:
  Fly   575 PEVHLAPLSQEELHAVQ------AQTPQISDPLIRCYPTHLEEASIQTS-----SRENATNPADD 628

  Fly   583 YAAGELVNLL-------EKLAQ---VMVEHGDTPDQAQRNCYEMYFDYL-------DPEMIWEVD 630
            |..||.|:.:       .|:|.   |:.:...|....:....|.|..:|       ||..|.:..
  Fly   629 YHVGEPVDGIRSFGVSKRKMAPLKFVLSQPKPTLKLEENRDDEEYTSFLPDFRRAGDPLAIHKET 693

  Fly   631 DATRDHIAAGFVLLNTSQNAEIV 653
            .||.|.        |||...|.:
  Fly   694 PATSDS--------NTSSEWEFL 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p	NP_001303455.1	WD40	<17..>132	CDD:225201	25/118 (21%)
		WD40	<21..128	CDD:295369	23/114 (20%)
		WD40 repeat	25..63	CDD:293791	9/36 (25%)
		WD40 repeat	68..107	CDD:293791	9/50 (18%)
		WD40 repeat	116..154	CDD:293791	10/37 (27%)
		WD40 repeat	161..196	CDD:293791	10/38 (26%)
		WD40 repeat	204..245	CDD:293791	16/42 (38%)
CG11141	NP_001286159.1	WD40 repeat	138..188	CDD:293791	16/54 (30%)
CG11141	NP_001286159.1	WD40 repeat	194..228	CDD:293791	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3621
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201801at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.780