Protein Alignment p and hps5

DIOPT Version :10

• Sequence 1: NP_649810.1
• Gene: p / 41025
• FlyBaseID: FBgn0086679
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_001083008.3
• Gene: hps5 / 100037388
• ZFINID: ZDB-GENE-070410-80
• Length: 1133
• Species: Danio rerio
• Alignment Length: 858
• Identity: 202/858 - (23%)
• Similarity: 335/858 - (39%)
• Gaps: 225/858 - (26%)

  Fly    26 RIKYTCFDISDSYIIFGASSGSLYLFNRNG-KFLLLIPNKHGAITSLSISANSK-YVAFATQRSL 88
            |||.||..:|..::..|.|:|.|:|..|:| |..|::.:|.|:||.:|...:.: ::|.||.:.|
Zfish    33 RIKCTCLSVSRKWLALGTSAGGLHLIQRDGWKQKLILTHKEGSITQVSCCPHDEDFIAVATSQGL 97

  Fly    89 ICVYAVNLSAQATPQ---VIFTHLDQSVQVTCIHWTQDEKQFYYGDSRGQVSLVLL-SSFIGHSL 149
            :.|:.::|..:..|:   |.:.|  :.|.||.:.|.....:.:.||..|:||.|.. ||.:|...
Zfish    98 VVVWELHLERRGRPERASVSWEH--RGVTVTSLCWDTVALRVFAGDVGGKVSCVRAGSSKLGKGS 160

  Fly   150 LFNM-TVHPLLYLDSPIVQIDDFEYLLLVSNCTKCILCNTEYEDYKQIGNRPRDGAFGACFFVSP 213
            .|.: .|..:..:||.:||:...:..|::|:.::|.||:||.|.:.::||:.|||.|||||..
Zfish   161 AFVIFPVQTITTVDSRVVQLGYTDGHLVISSLSRCYLCDTEREKFWRVGNKERDGEFGACFLT-- 223

  Fly   214 QESLQPSR----------IYCARPGSRVWEVDFEGEVIQTHQFKTALATAPARIQRPGSGTDELD 268
             :.|...|          ::|||||||:||..|.|||:.|||||..||..|..:.   |..:|..
Zfish   224 -QGLAGQRGQLVGCPAPLLFCARPGSRIWEASFSGEVLSTHQFKQLLAVPPLPLV---SCKNEPH 284

  Fly   269 ANAELLDYQPQNLQFAKVQRLNDDFLLAFTELGLYIFDIRRSAVVLWSNQFERIADCRSSGSEIF 333
            .|.  ....||:|.|.::.:..|..||.:|:..:|||......|:||: :.:.:.:.....:::|
Zfish   285 FNP--TQTNPQSLAFPRLLQFGDQNLLTWTDSAIYIFTPHSGQVLLWT-EVKDVLEISVFRNDLF 346

  Fly   334 VFTQSGALYSVQLQTLQSHAVSLIQQSKLLPCANL--LRQHVRYFADKAREDYELKQLNPLKQLL 396
            .....|.|..:.|.:.......|:::......|.:  :.||. ....|||:...:.:|..||..|
Zfish   347 CLHGDGRLSHMSLVSPDRCVERLMKRENWTIAATVCCMFQHA-ITTSKARKSLSIDRLEHLKAQL 410

  Fly   397 IERQEYELLNDISVIFDAI----TQCTG--SALDTHSS--------------GGS---------- 431
            ......:|:..:..:...:    :.|:.  |::.:|.|              .||
Zfish   411 NSTSHQQLIGQLEEVISKLEPLDSACSSRRSSISSHESFNVLDCGIYRVISRRGSQSDDDASSLA 475

  Fly   432 -------------SATTERSLSGGSSS--------------------RAPPK------------- 450
                         |.|.|..:...|:|                    ..||:
Zfish   476 NQSMFEEERLKEFSFTEEEQVDNDSASVRGEGDRSDLGLQFLPLPFRSKPPRVALQAVRDSVSSF 540

  Fly   451 -------------------------GVY--VLENA--FCDNLKQPLKTGH--FKDALLTVTGKFG 484
                                     ||.  |...|  ..:..:|.|.|.|  .:..||.:.....
Zfish   541 MKKTTEKINTLQMNADLWPRPDLREGVQGEVASTASPISEESEQELNTEHSGSESELLELRAATK 605

  Fly   485 KNIIKYKFNIFAEEQ---QQLVRELIPASERSLPFKDIKARYESGSEDQ---------------E 531
            |.|.:.:..:...:.   ..:::|..|..||:|           |.|||               |
Zfish   606 KAISQIQDPMVLLDPLCLSDVLQEWAPVLERAL-----------GPEDQILPVETTNPEEKTLEE 659

  Fly   532 EEIVRR---CKKPAPQV---PHISPEEKTLYNLYLIAKSAKFSR-TQC-VDRYRAVFDEYAAG-E 587
            ||:|..   |....|::   |...|:|...:     .:...||. |.| :...||.|...|.. |
Zfish   660 EELVSSMSCCVVVQPEISTSPAADPDESATH-----TEEEDFSESTPCSIAPVRAQFPPLANHVE 719

  Fly   588 LVNL-------------LEKLAQVMVEHGDTPDQA--QRNC--YEMYFDYLDPEMIWEVDDATRD 635
            |:.|             |..||.:.:|.| .|.:.  :..|  ...:|..||.|.:..:
Zfish   720 LIQLFSPKPLPPDLQADLSLLACLYLEMG-CPGRGGMESVCVFLRRFFFLLDQERVRRM------ 777

  Fly   636 HIAAGFVLLNTSQNAEIVKCEHCSFPLRFDTSCQYHELGAVLLRYFWSRGEQLKCFDVVQ----- 695
                  .:|...:|.|::|. :.:..|.|..:.:..|:        ..:|:.||....::
Zfish   778 ------CMLRYRENREVLKA-YIAGMLEFTQASKVVEV--------IQKGDLLKSLRSLRELQPW 827

  Fly   696 SVPALLDVLAKFY 708
            :.|.||..|.:.|
Zfish   828 NAPLLLSHLYRLY 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p	NP_649810.1	WD40	<20..148	CDD:441893	42/127 (33%)
		WD40 repeat	25..63	CDD:293791	15/37 (41%)
		WD40 repeat	68..107	CDD:293791	11/42 (26%)
		WD40 repeat	116..154	CDD:293791	12/39 (31%)
		WD40 repeat	161..196	CDD:293791	12/34 (35%)
		WD40 repeat	204..245	CDD:293791	21/50 (42%)
hps5	NP_001083008.3	None