DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p and hps5

DIOPT Version :9

Sequence 1:	NP_001303455.1	Gene:	p / 41025	FlyBaseID:	FBgn0086679	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001083008.2	Gene:	hps5 / 100037388	ZFINID:	ZDB-GENE-070410-80	Length:	1133	Species:	Danio rerio

Alignment Length:	845	Identity:	201/845 - (23%)
Similarity:	337/845 - (39%)	Gaps:	199/845 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RIKYTCFDISDSYIIFGASSGSLYLFNRNG-KFLLLIPNKHGAITSLSISANSK-YVAFATQRSL 88
            |||.||..:|..::..|.|:|.|:|..|:| |..|::.:|.|:||.:|...:.: ::|.||.:.|
Zfish    33 RIKCTCLSVSRKWLALGTSAGGLHLIQRDGWKQKLILTHKEGSITQVSCCPHDEDFIAVATSQGL 97

  Fly    89 ICVYAVNLSAQATPQ---VIFTHLDQSVQVTCIHWTQDEKQFYYGDSRGQVSLVLL-SSFIGHSL 149
            :.|:.::|..:..|:   |.:.|  :.|.||.:.|.....:.:.||..|:||.|.. ||.:|...
Zfish    98 VVVWELHLERRGRPERASVSWEH--RGVTVTSLCWDTVALRVFAGDMGGKVSCVRAGSSKLGKGS 160

  Fly   150 LFNM-TVHPLLYLDSPIVQIDDFEYLLLVSNCTKCILCNTEYEDYKQIGNRPRDGAFGACFFVSP 213
            .|.: .|..:..:||.:||:...:..|::|:.::|.||:||.|.:.::||:.|||.|||||..
Zfish   161 AFVIFPVQTVTTVDSRVVQLGYTDGHLVISSLSRCYLCDTEREKFWRVGNKERDGEFGACFLT-- 223

  Fly   214 QESLQPSR----------IYCARPGSRVWEVDFEGEVIQTHQFKTALATAPARIQRPGSGTDELD 268
             :.|...|          ::|||||||:||..|.|||:.|||||..||..|..:.   |..:|..
Zfish   224 -QGLAGQRGQLVGCPAPLLFCARPGSRIWEASFSGEVLSTHQFKQLLAVPPLPLV---SCKNEPH 284

  Fly   269 ANAELLDYQPQNLQFAKVQRLNDDFLLAFTELGLYIFDIRRSAVVLWSNQFERIADCRSSGSEIF 333
            .|.  ....||:|.|.::.:..|..||.:|:..:|||......|:||: :.:.:.:.....:::|
Zfish   285 FNP--TQTNPQSLAFPRLLQFGDQNLLTWTDSAIYIFTPHSGQVLLWT-EVKDVLEISVFRNDLF 346

  Fly   334 VFTQSGALYSVQLQTLQSHAVSLIQQSKLLPCANL--LRQHVRYFADKAREDYELKQLNPLKQLL 396
            .....|.|..:.|.:.......|:::......|.:  :.||. ....|||:...:.:|..||..|
Zfish   347 CLHGDGHLSHMSLVSPDRCVERLMKRENWTIAATVCCMFQHA-ITTSKARKSLSIDRLEHLKAQL 410

  Fly   397 IERQEYELLNDISVIFDAI----TQCTG--SALDTHSS---------------GGSSATTERSLS 440
            ....:.:|:..:..:...:    :.|:.  |::.:|.|               |..|.....||:
Zfish   411 NSTSQQQLIGQLEEVISKLEPLDSACSSRRSSISSHESFNVLDCGIYRVISRRGSQSDDDASSLA 475

  Fly   441 GGSS-SRAPPKGVYVLENAFCDN------------------LKQPLKTGHFKDALLTV---TGKF 483
            ..|. .....|.....|....||                  |..|.::...:.||..|   ...|
Zfish   476 NQSMLEEERLKEFSFTEEEQVDNDSASVRGEGDRSDLGLQFLPLPFRSKPPRVALQAVRDSVSSF 540

  Fly   484 GK------NIIKYKFNIFAEE------QQQLVRELIPASERSLPFKDIKARYESGSEDQEEEIVR 536
            .|      |.::...:::...      |.::.....|.||.|  .:::... ||.||.:..|:..
Zfish   541 MKKTTEKINTLQMNADLWPRPDLREGVQGEVASTASPISEES--EQELNTE-ESSSESELLELRA 602

  Fly   537 RCKKPAPQV--PHI----------------------------------SPEEKTLYNLYLIA--- 562
            ..||...|:  |.:                                  :||||||....|::
Zfish   603 ATKKAISQIQDPMVLLDPLCLSDVLQEWAPVLERALGPEDQILPVETTNPEEKTLEEEELVSSMS 667

  Fly   563 ------------------KSAKFSR-------TQC-VDRYRAVFDEYAAG-ELVNL--------- 591
                              :||..:.       |.| :...||.|...|.. ||:.|
Zfish   668 CCVVVQPEISTSPAADPDESATHTEEEDFRESTPCSIAPVRAQFPPLANHVELIQLFSPKPLPPD 732

  Fly   592 ----LEKLAQVMVEHGDTPDQA--QRNC--YEMYFDYLDPEMIWEVDDATRDHIAAGFVLLNTSQ 648
                |..||.:.:|.| .|.:.  :..|  ...:|..||.|.:..:            .:|...:
Zfish   733 LQADLSLLACLYLEMG-CPGRGGMESVCVFLRRFFFLLDQERVRRM------------CMLRYRE 784

  Fly   649 NAEIVKCEHCSFPLRFDTSCQYHELGAVLLRYFWSRGEQLKCFDVVQ-----SVPALLDVLAKFY 708
            |.|::|. :.:..|.|..:.:..|:        ..:|:.||....::     :.|.||..|.:.|
Zfish   785 NREVLKA-YIAGMLEFTQASKVVEV--------IQKGDLLKSLRSLRELQPWNAPLLLSHLYRLY 840

Fly 709 708
Zfish 841 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p	NP_001303455.1	WD40	<17..>132	CDD:225201	34/110 (31%)
		WD40	<21..128	CDD:295369	33/106 (31%)
		WD40 repeat	25..63	CDD:293791	15/37 (41%)
		WD40 repeat	68..107	CDD:293791	11/42 (26%)
		WD40 repeat	116..154	CDD:293791	12/39 (31%)
		WD40 repeat	161..196	CDD:293791	12/34 (35%)
		WD40 repeat	204..245	CDD:293791	21/50 (42%)
hps5	NP_001083008.2	WD40 repeat	36..71	CDD:293791	12/34 (35%)
		WD40 repeat	77..120	CDD:293791	10/42 (24%)
		WD40 repeat	125..163	CDD:293791	12/37 (32%)
		WD40 repeat	171..202	CDD:293791	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004653
OrthoInspector	1	1.000	-	-		otm24729
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23287
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4159
SonicParanoid	1	1.000	-	-		X5011
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.830