DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhod and ura3

DIOPT Version :9

Sequence 1:	NP_477224.1	Gene:	Dhod / 41022	FlyBaseID:	FBgn0000447	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_593317.1	Gene:	ura3 / 2542781	PomBaseID:	SPAC57A10.12c	Length:	443	Species:	Schizosaccharomyces pombe

Alignment Length:	421	Identity:	169/421 - (40%)
Similarity:	240/421 - (57%)	Gaps:	58/421 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LRSLGIVTVGGAALVAGITAYKNQD-----------QLFRTFVMPAVRLLPAEASHQLAVLACKY 72
            ||...:::|.| :..||:..|...|           .||..|..|       |.||::|:||..:
pombe    35 LRHWKLLSVIG-SFTAGVAIYDMSDVRSFIHGRIEMPLFHAFTTP-------EFSHRVAILAASW 91

  Fly    73 RLCPVSQYHDDQNLHTSFFGRMLSNPIGIAAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNP 137
            .:.|..:..||.:|....:|:...||||:||||||.|:|:.||.:.||.::|:|:|||..|.|||
pombe    92 GITPKDRVADDPSLAVEVWGKKFCNPIGLAAGFDKQADAISGLLNFGFSYLEIGSVTPKPQPGNP 156

  Fly   138 KPRVFRLTEDKAIINRYGFNSDGHQAVLQRLRLLRKK----------ENF--------------- 177
            |||.|||..|.::||||||||.||.|:|.:::...:|          :.|
pombe   157 KPRYFRLKPDLSVINRYGFNSIGHDAILAKIQKRVRKYIAKTSPQLLKQFDANPASCTDPAVLGV 221

  Fly   178 ------NGVVGVNLGRNKTTMSPIADYVQGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLREL 236
                  |..:|:|||:||.. :.|.|||:|||.||..||.||||||||||.|||::|.|..|..|
pombe   222 PRSLIPNKFLGINLGKNKNG-NEIEDYVEGVRTFGNFADILVINVSSPNTPGLRNLQKKSALSTL 285

  Fly   237 LEQVNDTKSSLDKNKNVPILLKLSPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSR-ENIEKN 300
            |..|...::.|: :.:.|:|:|::|||:.:::.||..|:  ||.::||:||.||||.| :.::..
pombe   286 LTAVVSERNKLN-SPHPPVLVKIAPDLNEEELTDIADVL--KKCKIDGVIVGNTTVQRPKTLKST 347

  Fly   301 KLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALV 365
            ...||||||||||||..:...:..:.:.....|||||.||::||.||.|...|||:.||:||||.
pombe   348 SHVEETGGLSGPPLKPIALNTLRTLRKHLSSDIPIIGCGGISSGKDAIEYARAGATMVQVYTALG 412

  Fly   366 YEGPALVEDIKAELSALITRLGHTNVADVVG 396
            |:||.:...||.|   ::..|......|::|
pombe   413 YDGPVIAHKIKQE---ILAELKGKRWVDIIG 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhod	NP_477224.1	PRK05286	45..387	CDD:235388	158/373 (42%)
Dhod	NP_477224.1	DHOD_2_like	51..379	CDD:240089	154/359 (43%)
ura3	NP_593317.1	PLN02826	42..431	CDD:178421	164/403 (41%)
ura3	NP_593317.1	DHOD_2_like	69..426	CDD:240089	158/370 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	260	1.000	Domainoid score	I373
eggNOG	1	0.900	-	-		E1_COG0167
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1043
Inparanoid	1	1.050	281	1.000	Inparanoid score	I670
OMA	1	1.010	-	-		QHG56580
OrthoFinder	1	1.000	-	-		FOG0003942
OrthoInspector	1	1.000	-	-		oto101254
orthoMCL	1	0.900	-	-		OOG6_101797
Panther	1	1.100	-	-	LDO	PTHR48109
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2249
SonicParanoid	1	1.000	-	-		X2714
TreeFam	1	0.960	-	-
	14	13.860