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Protein Alignment Dhod and DHODH

DIOPT Version :9

Sequence 1:	NP_477224.1	Gene:	Dhod / 41022	FlyBaseID:	FBgn0000447	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001352.2	Gene:	DHODH / 1723	HGNCID:	2867	Length:	395	Species:	Homo sapiens

Alignment Length:	401	Identity:	192/401 - (47%)
Similarity:	257/401 - (64%)	Gaps:	16/401 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HLKNAKNATRRVGRLRSLGIVTVGGAALVAGITAYKNQDQLFRTFVMPAVR-LLPAEASHQLAVL 68
            |||.         |.:...|:..||..|.|........::.:...:||.:: ||..|::|:|||.
Human     5 HLKK---------RAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR 60

  Fly    69 ACKYRLCPVSQYHDDQNLHTSFFGRMLSNPIGIAAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQ 133
            .....|.|.:::.|...|.....|....||:||||||||:.||||||..:||||:|:|:|||..|
Human    61 FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQ 125

  Fly   134 EGNPKPRVFRLTEDKAIINRYGFNSDGHQAVLQRLRLLRKKE---NFNGV-VGVNLGRNKTTMSP 194
            ||||:||||||.||:|:||||||||.|...|..|||..::|:   ..:|: :|||||:|||::..
Human   126 EGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDA 190

  Fly   195 IADYVQGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLKL 259
            ..||.:||||.||:|||||:|||||||.|||.:|.|.:||.||.:|...:..|.:.....:|:|:
Human   191 AEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKI 255

  Fly   260 SPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSRENIEKNKLAEETGGLSGPPLKARSTEMIAQ 324
            :|||:..|.:||..|:  |:..:|||||:||||||....:..|..|||||||.||:..||:.|.:
Human   256 APDLTSQDKEDIASVV--KELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIRE 318

  Fly   325 MYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAELSALITRLGHT 389
            ||.||.|::||||||||:||.||.|||.||||.||:||||.:.||.:|..:|.||.||:...|..
Human   319 MYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFG 383

  Fly   390 NVADVVGTNSK 400
            .|.|.:|.:.:
Human   384 GVTDAIGADHR 394

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.