DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dhod and DHODH

DIOPT Version :10

Sequence 1:NP_477224.1 Gene:Dhod / 41022 FlyBaseID:FBgn0000447 Length:405 Species:Drosophila melanogaster
Sequence 2:NP_001352.2 Gene:DHODH / 1723 HGNCID:2867 Length:395 Species:Homo sapiens


Alignment Length:401 Identity:192/401 - (47%)
Similarity:257/401 - (64%) Gaps:16/401 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 HLKNAKNATRRVGRLRSLGIVTVGGAALVAGITAYKNQDQLFRTFVMPAVR-LLPAEASHQLAVL 68
            |||.         |.:...|:..||..|.|........::.:...:||.:: ||..|::|:|||.
Human     5 HLKK---------RAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR 60

  Fly    69 ACKYRLCPVSQYHDDQNLHTSFFGRMLSNPIGIAAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQ 133
            .....|.|.:::.|...|.....|....||:||||||||:.||||||..:||||:|:|:|||..|
Human    61 FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQ 125

  Fly   134 EGNPKPRVFRLTEDKAIINRYGFNSDGHQAVLQRLRLLRKKE---NFNGV-VGVNLGRNKTTMSP 194
            ||||:||||||.||:|:||||||||.|...|..|||..::|:   ..:|: :|||||:|||::..
Human   126 EGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDA 190

  Fly   195 IADYVQGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLKL 259
            ..||.:||||.||:|||||:|||||||.|||.:|.|.:||.||.:|...:..|.:.....:|:|:
Human   191 AEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKI 255

  Fly   260 SPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSRENIEKNKLAEETGGLSGPPLKARSTEMIAQ 324
            :|||:..|.:||..|:  |:..:|||||:||||||....:..|..|||||||.||:..||:.|.:
Human   256 APDLTSQDKEDIASVV--KELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIRE 318

  Fly   325 MYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAELSALITRLGHT 389
            ||.||.|::||||||||:||.||.|||.||||.||:||||.:.||.:|..:|.||.||:...|..
Human   319 MYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFG 383

  Fly   390 NVADVVGTNSK 400
            .|.|.:|.:.:
Human   384 GVTDAIGADHR 394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DhodNP_477224.1 DHOD_2_like 51..379 CDD:240089 175/332 (53%)
DHODHNP_001352.2 DHOD_2_like 45..373 CDD:240089 173/329 (53%)

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