Protein Alignment Mkk4 and MKK2

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_015185.1
• Gene: MKK2 / 855963
• SGDID: S000006061
• Length: 506
• Species: Saccharomyces cerevisiae
• Alignment Length: 517
• Identity: 153/517 - (29%)
• Similarity: 218/517 - (42%)
• Gaps: 141/517 - (27%)

  Fly     5 PKNLFATGSSRSRNPPDQLSLNN---LSIRHPPSSTSSTSSGSTSSGSSSSS----QHNHVTRCF 62
            |.||.....|.:    |...||.   .|:...|.|.:|||:.||:|..:|:|    ..:..|...
Yeast    23 PVNLVQNAKSTN----DGQHLNRSPYSSVNESPYSNNSTSATSTTSSMASNSTLLYNRSSTTTIK 83

  Fly    63 GAQQPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHT----------- 116
            ....|...||:..:|               .::.|..:..|..|..|..:|.|.
Yeast    84 NRPVPPPLPPLVLTQ---------------KKDGIEYRVAGDSQLSERFSNLHVDITYKELLSSA 133

  Fly   117 ------------------------------------FTS-------------------------D 120
                                                |:|                         |
Yeast   134 PISTKLSNIDTTFIKKDLDTPEGEDSYPSTLLSAYDFSSSGSNSAPLSANNIISCSNLIQGKDVD 198

  Fly   121 DLEDE--------------GEIGRGAFGAVNKMTFKKLDKVMAVKRIRS-TVDEKEQKQLLMDLE 170
            .||:|              |.:|.||.|:|.|...|...||.|:|.|.: ..|.:.|||:..:|:
Yeast   199 QLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQ 263

  Fly   171 VVMKSNECIYIVQFYGALFKE--GDCWICMELM-DTSLDKFYKYIYEKQQRHIPESILAKITVAT 232
             ..||.:..||||:||....|  ...:|.||.| ..||:..||.:.::..| |.|.::.||..:.
Yeast   264 -FNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR-ISERVIGKIAESV 326

  Fly   233 VNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDP 297
            :..|:||.|. |:||||:||.||||:.:|:|||||||:||:.|:|:|.| ..|...|||||||
Yeast   327 LRGLSYLHER-KVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMT-FTGTSFYMAPERI-- 387

  Fly   298 ERAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSV------FEQLCQVVQGEP-----PRLLTSY 351
             :.:.|.|..||||||:||:|||.|.||:.. |.:      .|.|..::...|     |.|
Yeast   388 -QGQPYSVTCDVWSLGLTLLEVAGGRFPFES-DKITQNVAPIELLTMILTFSPQLKDEPEL---- 446

  Fly   352 NGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVADILESMEKDGI 413
             .:.:||.|..|::.||.|...:||...::|:.|:|........::..:|....|. |||||
Yeast   447 -DISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERFVKKCWEK-EKDGI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	119/390 (31%)
MKK2	NP_015185.1	PKc_Pek1_like	212..499	CDD:270793	112/299 (37%)