DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and STE7

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_010122.1	Gene:	STE7 / 851396	SGDID:	S000002318	Length:	515	Species:	Saccharomyces cerevisiae

Alignment Length:	404	Identity:	131/404 - (32%)
Similarity:	193/404 - (47%)	Gaps:	72/404 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SSRSRNPP---DQLSLNNLSIRHPPSSTSSTSS---GSTSSGSSSSSQHNHVTRCFGAQQPQQTP 71
            ||.|.:.|   |..| ||..:  .||||:||.|   |.::..:...::|
Yeast   110 SSSSLSTPCIIDAYS-NNFGL--SPSSTNSTPSTIQGLSNIATPVENEH---------------- 155

  Fly    72 PVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAV 136
               |..:||:..:.|.:|||. ::.:           .|.:|.:.....||...|:||.|..|.|
Yeast   156 ---SISLPPLEESLSPAAADL-KDTL-----------SGTSNGNYIQLQDLVQLGKIGAGNSGTV 205

  Fly   137 NKMTFKKLDKVMAVKRI-----RSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKE---GD 193
            .|.......|::|.|.|     .||:    ..||:.:|.:|........|:.||||.:.:   .:
Yeast   206 VKALHVPDSKIVAKKTIPVEQNNSTI----INQLVRELSIVKNVKPHENIITFYGAYYNQHINNE 266

  Fly   194 CWICMELMDT-SLDKF---YKYIYEK-----QQRHIPESILAKITVATVNALNYLKEELKIIHRD 249
            ..|.||..|. ||||.   ||...::     ::....|..::||....:|.|::|..:.||||||
Yeast   267 IIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRD 331

  Fly   250 VKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGI 314
            :||||:|::.:|.|||||||:|.:|::|||.| ..|...||:||||   :...|.::.||||||:
Yeast   332 IKPSNVLINSKGQIKLCDFGVSKKLINSIADT-FVGTSTYMSPERI---QGNVYSIKGDVWSLGL 392

  Fly   315 TLMEVATGNFPYRKW----DSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDR 375
            .::|:.||.||....    |.:.:.|.::|....|||   .....:|||..||||.|.||.|.:|
Yeast   393 MIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRL---PKDRIYSKEMTDFVNRCCIKNERER 454

  Fly   376 PKYSRLLEMPFIRR 389
            .....||....|.:
Yeast   455 SSIHELLHHDLIMK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	105/296 (35%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	102/284 (36%)
STE7	NP_010122.1	PKc_Byr1_like	185..482	CDD:270792	105/295 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040