Protein Alignment Mkk4 and STK24

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_003567.2
• Gene: STK24 / 8428
• HGNCID: 11403
• Length: 443
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 99/311 - (31%)
• Similarity: 155/311 - (49%)
• Gaps: 50/311 - (16%)

  Fly   127 EIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLE---VVMKSNECIYIVQFYGAL 188
            :||:|:||.|.|....:..||:|:|    .:|.:|.:..:.|::   .|:...:..|:.::||:.
Human    41 KIGKGSFGEVFKGIDNRTQKVVAIK----IIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 101

  Fly   189 FKEGDCWICMELM--DTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVK 251
            .|:...||.||.:  .::||..       :...:.|:.:|.|....:..|:||..|.| ||||:|
Human   102 LKDTKLWIIMEYLGGGSALDLL-------EPGPLDETQIATILREILKGLDYLHSEKK-IHRDIK 158

  Fly   252 PSNILLHRRGDIKLCDFGISGQLVDS-IAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGIT 315
            .:|:||...|::||.|||::|||.|: |.:....|...:||||.|   :...||.::|:||||||
Human   159 AANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---KQSAYDSKADIWSLGIT 220

  Fly   316 LMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSR 380
            .:|:|.|..|:.:...: :.|..:.:..||.|..:|     ||...:||..||.|:.|.||....
Human   221 AIELARGEPPHSELHPM-KVLFLIPKNNPPTLEGNY-----SKPLKEFVEACLNKEPSFRPTAKE 279

  Fly   381 LLEMPFIRR-------------------GETSHTDVAVYVADILESMEKDG 412
            ||:..||.|                   .|.||.|.:...:|    .|.||
Human   280 LLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD----AETDG 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	96/302 (32%)
STK24	NP_003567.2	STKc_MST3_like	34..307	CDD:270786	91/286 (32%)
		Bipartite nuclear localization signal	278..292		5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..337		8/22 (36%)
		Nuclear export signal (NES)	335..386