DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and MKK2

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001031751.1	Gene:	MKK2 / 829103	AraportID:	AT4G29810	Length:	372	Species:	Arabidopsis thaliana

Alignment Length:	401	Identity:	117/401 - (29%)
Similarity:	185/401 - (46%)	Gaps:	76/401 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NNLSIRHPPSSTSS--------------TSSGSTSSGSSSSSQHNHVTRCFGAQQPQQTPPVASS 76
            |||.:..|.:...|              |.||:...|....::..  .|.....:|:...|:.
plant     8 NNLKLAIPVAGEQSITKFLRKGFGSLCRTQSGTFKDGDLRVNKDG--VRIISQLEPEVLSPIK-- 68

  Fly    77 QVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMTF 141
                 ||....|.:|....::                              ||:|:.|.|..:..
plant    69 -----PADDQLSLSDLDMVKV------------------------------IGKGSSGVVQLVQH 98

  Fly   142 KKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMD-TSL 205
            |...:..|:|.|:..:||..:|.:..:|: :.:|::|..:|..|.:.:..|...:.:|.|| .||
plant    99 KWTGQFFALKVIQLNIDEAIRKAIAQELK-INQSSQCPNLVTSYQSFYDNGAISLILEYMDGGSL 162

  Fly   206 DKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGI 270
            ..|.|.:     :.||:|.|:.|....:..|.||..:..|||||:||||:|::.||::|:.|||:
plant   163 ADFLKSV-----KAIPDSYLSAIFRQVLQGLIYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGV 222

  Fly   271 SGQLVDS--IAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY------R 327
            |..:.::  :|.| ..|...||:||||...:   |..:||:||||:.::|.|||.|||      .
plant   223 STVMTNTAGLANT-FVGTYNYMSPERIVGNK---YGNKSDIWSLGLVVLECATGKFPYAPPNQEE 283

  Fly   328 KWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGET 392
            .|.|||| |.:.:..:||..|.|.|   ||.|...|::|||.|..:.|.....|:|.||:.:.:.
plant   284 TWTSVFE-LMEAIVDQPPPALPSGN---FSPELSSFISTCLQKDPNSRSSAKELMEHPFLNKYDY 344

  Fly   393 SHTDVAVYVAD 403
            |..::|.|..|
plant   345 SGINLASYFTD 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	101/298 (34%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	96/272 (35%)
MKK2	NP_001031751.1	PKc_MAPKK	77..344	CDD:270782	98/310 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920