DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mkk4 and STK10

DIOPT Version :10

Sequence 1:NP_477353.1 Gene:Mkk4 / 41020 FlyBaseID:FBgn0024326 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_005981.3 Gene:STK10 / 6793 HGNCID:11388 Length:968 Species:Homo sapiens


Alignment Length:302 Identity:101/302 - (33%)
Similarity:162/302 - (53%) Gaps:35/302 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 GEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFK 190
            ||:|.||||.|.|...|:...:.|.|.| .|..|:|.:..::::|::...:. .|||:..||.:.
Human    40 GELGDGAFGKVYKAKNKETGALAAAKVI-ETKSEEELEDYIVEIEILATCDH-PYIVKLLGAYYH 102

  Fly   191 EGDCWICMEL-----MDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDV 250
            :|..||.:|.     :|..:.:..:.:.|.|.:.:...:|        .|||:|..: :|||||:
Human   103 DGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQML--------EALNFLHSK-RIIHRDL 158

  Fly   251 KPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPY-MAPERIDPERAKG--YDVRSDVWSL 312
            |..|:|:...|||:|.|||:|.:.:.::.|.......|| ||||.:..|..|.  ||.::|:|||
Human   159 KAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSL 223

  Fly   313 GITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPK 377
            ||||:|:|....|:.:.:.: ..|.::.:.:||.|||.   .::|.||.||:...|.|....||.
Human   224 GITLIEMAQIEPPHHELNPM-RVLLKIAKSDPPTLLTP---SKWSVEFRDFLKIALDKNPETRPS 284

  Fly   378 YSRLLEMPFIRRGETSHTD-------VAVYVADILESMEKDG 412
            .::|||.||:    :|.|.       ||...|:::|.:| ||
Human   285 AAQLLEHPFV----SSITSNKALRELVAEAKAEVMEEIE-DG 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mkk4NP_477353.1 PKc_MKK4 115..405 CDD:270790 97/293 (33%)
STK10NP_005981.3 STKc_STK10 23..314 CDD:132975 97/292 (33%)
Activation segment 175..224 18/48 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 337..411
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..490
PKK 587..725 CDD:463600
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..690
PKK 755..895 CDD:463600
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 827..865
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..929
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..968
Blue background indicates that the domain is not in the aligned region.

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