Protein Alignment Mkk4 and STK3

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_016869245.1
• Gene: STK3 / 6788
• HGNCID: 11406
• Length: 580
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 97/295 - (32%)
• Similarity: 160/295 - (54%)
• Gaps: 31/295 - (10%)

  Fly   120 DDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQF 184
            |.||   ::|.|::|:|.|...|:..:|:|:|::..   |.:.::::.::. :|:..:..|:|::
Human   113 DVLE---KLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEIS-IMQQCDSPYVVKY 170

  Fly   185 YGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRD 249
            ||:.||..|.||.||.....   ....|...:.:.:.|..:|.|..:|:..|.|| ..::.||||
Human   171 YGSYFKNTDLWIVMEYCGAG---SVSDIIRLRNKTLIEDEIATILKSTLKGLEYL-HFMRKIHRD 231

  Fly   250 VKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPY-MAPERIDPERAKGYDVRSDVWSLG 313
            :|..||||:..|..||.|||::|||.|::||.......|: ||||.|   :..||:..:|:||||
Human   232 IKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVADIWSLG 293

  Fly   314 ITLMEVATGNFPY---RKWDSVFEQLCQVVQGEPPRLLTSYNGME-FSKEFVDFVNTCLIKKESD 374
            ||.:|:|.|..||   ....::|     ::...||   .::...| :|.:|.|||..||:|....
Human   294 ITSIEMAEGKPPYADIHPMRAIF-----MIPTNPP---PTFRKPELWSDDFTDFVKKCLVKNPEQ 350

  Fly   375 RPKYSRLLEMPFIRRGETSHTDVAVYVADILESME 409
            |...::||:.|||:..:    .|::....|.|:||
Human   351 RATATQLLQHPFIKNAK----PVSILRDLITEAME 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	93/289 (32%)
STK3	XP_016869245.1	STKc_MST1_2	108..363	CDD:132943	90/271 (33%)