DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and map2k6

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_021335833.1	Gene:	map2k6 / 65239	ZFINID:	ZDB-GENE-010202-3	Length:	416	Species:	Danio rerio

Alignment Length:	374	Identity:	178/374 - (47%)
Similarity:	239/374 - (63%)	Gaps:	39/374 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 QPQQTPPVASSQVPPVPAASSSSAA---------------DRHRERIRQQACGKLQFGEG----- 110
            |.::|..|..|::|.:.:.||.|.|               ||.::..::....|..|.:.
Zfish    46 QMEKTHLVLPSRLPLLHSLSSHSLALSHLPSQDLEPLGLSDRKKKLPKELKLPKEVFEKPAPAPT 110

  Fly   111 -------------GANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQ 162
                         |.......:||||..||:||||:|.|:||.......:|||||||:||:.:||
Zfish   111 PPRDLDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQ 175

  Fly   163 KQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAK 227
            |:|||||::.|::.:|.|.|.||||||:|||.||||||||||||||||.::|| .:.|||.||.|
Zfish   176 KRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEK-GKTIPEDILGK 239

  Fly   228 ITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAP 292
            |||:.|.||.:|...|.:|||||||||:|::.:|.:|:|||||||.||||:|||.||||:|||||
Zfish   240 ITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAP 304

  Fly   293 ERIDPE-RAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEF 356
            |||:|| ..|||:|:||:||||||::|:|...|||..|.:.|:||.|||:...|:|...    .|
Zfish   305 ERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD----RF 365

  Fly   357 SKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVADIL 405
            |.:||||.:.||.|..::||.|:.|::.||....::..||||.:|..||
Zfish   366 SADFVDFTSQCLRKNSTERPTYTELMQHPFFTLHDSKDTDVASFVKTIL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	162/290 (56%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	153/264 (58%)
map2k6	XP_021335833.1	PKc_MKK3_6	133..415	CDD:173729	164/287 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.860