DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and MAP2K7

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_006722863.1	Gene:	MAP2K7 / 5609	HGNCID:	6847	Length:	442	Species:	Homo sapiens

Alignment Length:	433	Identity:	186/433 - (42%)
Similarity:	242/433 - (55%)	Gaps:	59/433 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ERPKNLFATGSSRSRNPPD----QLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFG 63
            :||:.:.....|.:..|..    ||.|.|             ..||.|..|.||.||
Human    37 QRPRPIIVITLSPAPAPSQRAALQLPLAN-------------DGGSRSPSSESSPQH-------- 80

  Fly    64 AQQPQQTPPVASSQVPPVPA------ASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDL 122
                 .|||.....:..:|:      :..|...|:..:.|.:|. |.|..   |...:....:||
Human    81 -----PTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQT-GYLTI---GGQRYQAEINDL 136

  Fly   123 EDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGA 187
            |:.||:|.|..|.|.||.|:|...|:|||::|.:.:::|.|::||||:||:||::|.||||.:|.
Human   137 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 201

  Fly   188 LFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKP 252
            .....|.:|.||||.|..:|..|    :.|..|||.||.|:|||.|.||.||||:..:|||||||
Human   202 FITNTDVFIAMELMGTCAEKLKK----RMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKP 262

  Fly   253 SNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDP--ERAKGYDVRSDVWSLGIT 315
            |||||..||.||||||||||:||||.|||:.|||..|||||||||  .....||:|:|||||||:
Human   263 SNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGIS 327

  Fly   316 L-------MEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKES 373
            |       :|:|||.|||:...:.||.|.:|:|.||| ||..:.|  ||.:|..||..||.|...
Human   328 LPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPP-LLPGHMG--FSGDFQSFVKDCLTKDHR 389

  Fly   374 DRPKYSRLLEMPFIRRGETSHTDVAVYVADIL---ESMEKDGI 413
            .||||::|||..||:|.||...|||.:..|::   ||....|:
Human   390 KRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGV 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	156/298 (52%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	145/272 (53%)
MAP2K7	XP_006722863.1	PKc_MKK7	120..423	CDD:270791	159/312 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920