Protein Alignment Mkk4 and MAP2K6

DIOPT Version :9

• Sequence 1: NP_001163551.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_011523328.1
• Gene: MAP2K6 / 5608
• HGNCID: 6846
• Length: 337
• Species: Homo sapiens
• Alignment Length: 342
• Identity: 172/342 - (50%)
• Similarity: 223/342 - (65%)
• Gaps: 31/342 - (9%)

  Fly    65 QQPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIG 129
            :|||      :|..||              ..:..:||..:     |.......:||||...|:|
Human    24 EQPQ------TSSTPP--------------RDLDSKACISI-----GNQNFEVKADDLEPIMELG 63

  Fly   130 RGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDC 194
            |||:|.|.||......::|||||||:||:.:|||:|||||::.|::.:|.:.|.||||||:|||.
Human    64 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDV 128

  Fly   195 WICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHR 259
            ||||||||||||||||.:.:|.|. |||.||.||.|:.|.||.:|..:|.:|||||||||:|::.
Human   129 WICMELMDTSLDKFYKQVIDKGQT-IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 192

  Fly   260 RGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRSDVWSLGITLMEVATGN 323
            .|.:|:|||||||.||||:|||.||||:||||||||:|| ..|||.|:||:||||||::|:|...
Human   193 LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 257

  Fly   324 FPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIR 388
            |||..|.:.|:||.|||:...|:|...    :||.|||||.:.||.|...:||.|..|::.||..
Human   258 FPYDSWGTPFQQLKQVVEEPSPQLPAD----KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 318

  Fly   389 RGETSHTDVAVYVADIL 405
            ..|:..||||.:|..||
Human   319 LHESKGTDVASFVKLIL 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	161/290 (56%)
		S_TKc	123..387	CDD:214567	151/264 (57%)
MAP2K6	XP_011523328.1	PKc_MKK3_6	54..336	CDD:173729	163/287 (57%)
		S_TKc	57..317	CDD:214567	151/264 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.860