DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and MAP2K5

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_660143.1	Gene:	MAP2K5 / 5607	HGNCID:	6845	Length:	448	Species:	Homo sapiens

Alignment Length:	410	Identity:	142/410 - (34%)
Similarity:	201/410 - (49%)	Gaps:	79/410 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PKNLFATGSSRSRNPPDQLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQ 69
            |..:|    .|:..||.:.:::.|.:             :|.:|.|                 |.
Human   101 PLQIF----PRACKPPGERNIHGLKV-------------NTRAGPS-----------------QH 131

  Fly    70 TPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFG 134
            :.|..|..:|      |:|......|..:..|.|::            ...|:.....:|.|..|
Human   132 SSPAVSDSLP------SNSLKKSSAELKKILANGQM------------NEQDIRYRDTLGHGNGG 178

  Fly   135 AVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICME 199
            .|.|.......|::|||.|...:..:.|||::.:||::.|.:.. ||:.||||.|.|....||.|
Human   179 TVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS-YIIGFYGAFFVENRISICTE 242

  Fly   200 LMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDI 263
            .|| .|||     :|.|    :||.:|.:|.||.|..|.|| ..|||:||||||||:|::.||.:
Human   243 FMDGGSLD-----VYRK----MPEHVLGRIAVAVVKGLTYL-WSLKILHRDVKPSNMLVNTRGQV 297

  Fly   264 KLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY-- 326
            ||||||:|.|||:|||||. .|...|||||||..|:   |.:.||||||||:.||:|.|.|||
Human   298 KLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGEQ---YGIHSDVWSLGISFMELALGRFPYPQ 358

  Fly   327 --RKWDSVFE-QLCQ-VVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI 387
              :...|:.. ||.| :|..:.|.|...    |||:.||.|:..|:.|:..:||....|:..|||
Human   359 IQKNQGSLMPLQLLQCIVDEDSPVLPVG----EFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 419

  Fly   388 -RRGETSHTDVAVYVADILE 406
             :..:.:...|:::|...||
Human   420 VQFNDGNAAVVSMWVCRALE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	122/297 (41%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	117/270 (43%)
MAP2K5	NP_660143.1	PB1_Map2k5	17..107	CDD:99717	2/9 (22%)
		Interaction with MAPK7. /evidence=ECO:0000250	18..25
		Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000250	64..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..144		9/63 (14%)
		Interaction with MAPK7. /evidence=ECO:0000250	117..131		4/43 (9%)
		PKc_MKK5	164..442	CDD:132950	124/295 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920