DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mkk4 and MAP2K5

DIOPT Version :10

Sequence 1:NP_477353.1 Gene:Mkk4 / 41020 FlyBaseID:FBgn0024326 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_660143.1 Gene:MAP2K5 / 5607 HGNCID:6845 Length:448 Species:Homo sapiens


Alignment Length:410 Identity:142/410 - (34%)
Similarity:201/410 - (49%) Gaps:79/410 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 PKNLFATGSSRSRNPPDQLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQ 69
            |..:|    .|:..||.:.:::.|.:             :|.:|.|                 |.
Human   101 PLQIF----PRACKPPGERNIHGLKV-------------NTRAGPS-----------------QH 131

  Fly    70 TPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFG 134
            :.|..|..:|      |:|......|..:..|.|::            ...|:.....:|.|..|
Human   132 SSPAVSDSLP------SNSLKKSSAELKKILANGQM------------NEQDIRYRDTLGHGNGG 178

  Fly   135 AVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICME 199
            .|.|.......|::|||.|...:..:.|||::.:||::.|.:.. ||:.||||.|.|....||.|
Human   179 TVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS-YIIGFYGAFFVENRISICTE 242

  Fly   200 LMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDI 263
            .|| .|||     :|.|    :||.:|.:|.||.|..|.|| ..|||:||||||||:|::.||.:
Human   243 FMDGGSLD-----VYRK----MPEHVLGRIAVAVVKGLTYL-WSLKILHRDVKPSNMLVNTRGQV 297

  Fly   264 KLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPY-- 326
            ||||||:|.|||:|||||. .|...|||||||..|:   |.:.||||||||:.||:|.|.|||  
Human   298 KLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGEQ---YGIHSDVWSLGISFMELALGRFPYPQ 358

  Fly   327 --RKWDSVFE-QLCQ-VVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI 387
              :...|:.. ||.| :|..:.|.|...    |||:.||.|:..|:.|:..:||....|:..|||
Human   359 IQKNQGSLMPLQLLQCIVDEDSPVLPVG----EFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 419

  Fly   388 -RRGETSHTDVAVYVADILE 406
             :..:.:...|:::|...||
Human   420 VQFNDGNAAVVSMWVCRALE 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mkk4NP_477353.1 PKc_MKK4 115..405 CDD:270790 122/297 (41%)
MAP2K5NP_660143.1 PB1_Map2k5 17..107 CDD:99717 2/9 (22%)
Interaction with MAPK7. /evidence=ECO:0000250 18..25
Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000250 64..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..144 9/63 (14%)
Interaction with MAPK7. /evidence=ECO:0000250 117..131 4/43 (9%)
PKc_MKK5 164..442 CDD:132950 124/295 (42%)
Blue background indicates that the domain is not in the aligned region.

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