Protein Alignment Mkk4 and MAP2K3

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_016880346.2
• Gene: MAP2K3 / 5606
• HGNCID: 6843
• Length: 466
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 169/358 - (47%)
• Similarity: 225/358 - (62%)
• Gaps: 45/358 - (12%)

  Fly    67 PQQTP----------------PVASSQVPP--VPAASSSSAADRHRERIRQQACGKLQFGEGGAN 113
            ||:.|                |.|.:..||  :.:.:..:..||:.|
Human   131 PQRDPGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFE------------------ 177

  Fly   114 THTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNEC 178
               ..:|||....|:||||:|.|.|:...:...:|||||||:||:.:|||:|||||::.|::.:|
Human   178 ---VEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC 239

  Fly   179 IYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEEL 243
            .|.|.||||||:|||.|||||||||||||||:.:.:|... |||.||.:|.|:.|.||.:|..:|
Human   240 FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMT-IPEDILGEIAVSIVRALEHLHSKL 303

  Fly   244 KIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRS 307
            .:|||||||||:|:::.|.:|:|||||||.||||:|||.||||:||||||||:|| ..|||:|:|
Human   304 SVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKS 368

  Fly   308 DVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKE 372
            ||||||||::|:|...|||..|.:.|:||.|||:...|:|...    .||.|||||...||.|..
Human   369 DVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD----RFSPEFVDFTAQCLRKNP 429

  Fly   373 SDRPKYSRLLEMPFIRRGETSHTDVAVYVADIL 405
            ::|..|..|:|.||....:|..||:|.:|.:||
Human   430 AERMSYLELMEHPFFTLHKTKKTDIAAFVKEIL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	157/290 (54%)
MAP2K3	XP_016880346.2	PKc_MKK3_6	181..463	CDD:173729	159/287 (55%)