Protein Alignment Mkk4 and MAP2K2

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_109587.1
• Gene: MAP2K2 / 5605
• HGNCID: 6842
• Length: 400
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 134/406 - (33%)
• Similarity: 200/406 - (49%)
• Gaps: 80/406 - (19%)

  Fly    71 PPVASSQVPPVPAASSSSAAD------------RHRERIRQQACGKLQFGEGGANTHTFTSDDLE 123
            |.:|....|....||.::..|            :.::|:......|.:.||       ...||.|
Human    16 PTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGE-------LKDDDFE 73

  Fly   124 DEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGAL 188
            ...|:|.|..|.|.|:..:....:||.|.|...:....:.|::.:|:|:.:.|. .|||.||||.
Human    74 RISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIVGFYGAF 137

  Fly   189 FKEGDCWICMELMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKP 252
            :.:|:..||||.|| .|||:..     |:.:.|||.||.|:::|.:..|.||:|:.:|:||||||
Human   138 YSDGEISICMEHMDGGSLDQVL-----KEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKP 197

  Fly   253 SNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLM 317
            ||||::.||:|||||||:||||:||:|.: ..|.|.||||||:   :...|.|:||:||:|::|:
Human   198 SNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMAPERL---QGTHYSVQSDIWSMGLSLV 258

  Fly   318 EVATGNFPYRKWD---------------------------------------------SVFEQLC 337
            |:|.|.:|....|                                             ::||.|.
Human   259 ELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLD 323

  Fly   338 QVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVA 402
            .:|...||:|   .||: |:.:|.:|||.||||..::|.....|....||:|.|....|.|.::.
Human   324 YIVNEPPPKL---PNGV-FTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLC 384

  Fly   403 DILESMEKDGITQFTA 418
            ..|. :.:.|....||
Human   385 KTLR-LNQPGTPTRTA 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	120/335 (36%)
MAP2K2	NP_109587.1	PKc_MEK2	66..396	CDD:132980	123/351 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..310		0/23 (0%)