DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and map2k1

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001008058.1	Gene:	map2k1 / 493420	XenbaseID:	XB-GENE-478822	Length:	395	Species:	Xenopus tropicalis

Alignment Length:	393	Identity:	130/393 - (33%)
Similarity:	195/393 - (49%)	Gaps:	76/393 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 QQTPPVASSQVPPVPAASSSSAA-----------DRHRERIRQQACGKLQFGEGGANTHTFTSDD 121
            |..|....:.|...|.|.::..|           ::.|:|:......|.:.||       ...||
Frog    10 QLNPNPEGTAVNGTPTAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGE-------LKDDD 67

  Fly   122 LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYG 186
            .|...|:|.|..|.|.|::.|....:||.|.|...:....:.|::.:|:|:.:.|. .|||.|||
Frog    68 FEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIVGFYG 131

  Fly   187 ALFKEGDCWICMELMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDV 250
            |.:.:|:..||||.|| .|||:..     |:...|||.||.|:::|.:..|.||:|:.||:||||
Frog   132 AFYSDGEISICMEHMDGGSLDQVL-----KKAGKIPEKILGKVSIAVIKGLTYLREKHKIMHRDV 191

  Fly   251 KPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGIT 315
            ||||||::.||:|||||||:||||:||:|.: ..|.|.||:|||:   :...|.|:||:||:|::
Frog   192 KPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL---QGTHYSVQSDIWSMGLS 252

  Fly   316 LMEVATGNFPYRKWD-------------------------------------------SVFEQLC 337
            |:|:|.|.:|....|                                           ::||.|.
Frog   253 LVEMAIGRYPIPPPDAKELELIFGCSVEGDPASSELAPRPRPPGRPISSYGPDSRPPMAIFELLD 317

  Fly   338 QVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVA 402
            .:|...||:|.:..    |..||.||||.||:|..::|....:|:...||::.|....|.|.::.
Frog   318 YIVNEPPPKLPSGV----FGAEFQDFVNKCLVKNPAERADLKQLMVHSFIKQSELEEVDFAGWLC 378

  Fly   403 DIL 405
            ..:
Frog   379 STM 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	119/333 (36%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	112/307 (36%)
map2k1	NP_001008058.1	PKc_MEK1	62..382	CDD:270816	120/341 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950