DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and msn

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	95/305 - (31%)
Similarity:	143/305 - (46%)	Gaps:	46/305 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALF--- 189
            :|.|.:|.|.|....|..::.|:|.:..|.||:|  ::.:::.|:.|.:....|..:|||..
  Fly    38 VGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEE--EIKLEINVLKKYSNHRNIATYYGAFIKKS 100

  Fly   190 ---KEGDCWICMELMD----TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIH 247
               |:...|:.||...    |.|.|..|      .:.:.|..:|.|....:..|:||... |:||
  Fly   101 PPGKDDQLWLVMEYCGAGSVTDLVKSTK------GQSLKEEWIAYICREILRGLSYLHSN-KVIH 158

  Fly   248 RDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPY-MAPERI--DPERAKGYDVRSDV 309
            ||:|..|:||....::||.|||:|.||..:|.:.......|| ||||.|  |......||.|||:
  Fly   159 RDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDL 223

  Fly   310 WSLGITLMEVATGNFPYRKWDSVFEQLCQ---------VVQGEPPRLLTSYNGMEFSKEFVDFVN 365
            ||||||.:|:|....|          ||.         :.:..||||    ...::||:|..|::
  Fly   224 WSLGITALEMAESQPP----------LCDLHPMRALFLIPRNSPPRL----KSKKWSKKFHGFID 274

  Fly   366 TCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYVADILESMEK 410
            |.|:|....||....||:..||:...|.. .|.:.:.|.::..:|
  Fly   275 TVLVKDYHQRPYTENLLKHGFIKDQPTDR-QVRIQLKDHIDRCKK 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	94/298 (32%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	89/280 (32%)
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	89/280 (32%)
		S_TKc	32..296	CDD:214567	89/280 (32%)
		CNH	1183..1484	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910