Protein Alignment Mkk4 and map2k1

DIOPT Version :9

• Sequence 1: NP_001163551.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_998584.2
• Gene: map2k1 / 406728
• ZFINID: ZDB-GENE-040426-2759
• Length: 395
• Species: Danio rerio
• Alignment Length: 412
• Identity: 130/412 - (31%)
• Similarity: 200/412 - (48%)
• Gaps: 89/412 - (21%)

  Fly    65 QQPQQTPPVASSQVPPVPAASSSSAA-----------------DRHRERIRQQACGKLQFGEGGA 112
            |:.::..|:..:.:|...|.:.:.|.                 ::.::|:......|.:.||
Zfish     2 QKRRKPEPIQLNPIPDGNAINGTGATETNLEALQKKLEELELDEQQKKRLEAFLTQKQKVGE--- 63

  Fly   113 NTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNE 177
                ...||.|...|:|.|..|.|.|:..:....:||.|.|...:....:.|::.:|:|:.:.|.
Zfish    64 ----LKDDDFEKISELGAGNGGVVFKVLHRPSGFIMARKLIHLEIKPAIRNQIIRELQVLHECNS 124

  Fly   178 CIYIVQFYGALFKEGDCWICMELMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKE 241
             .|||.||||.:.:|:..||||.|| .|||:..     |:...|||.||.|:::|.:..|:||:|
Zfish   125 -PYIVGFYGAFYSDGEISICMENMDGGSLDQCL-----KKAGKIPEQILGKVSIAVIKGLSYLRE 183

  Fly   242 ELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVR 306
            :.||:||||||||||::.||:|||||||:||||:||:|.: ..|.|.||:|||:   :...|.|:
Zfish   184 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL---QGTHYSVQ 244

  Fly   307 SDVWSLGITLMEVATGNFPYRKWD----------------------------------------- 330
            .|:||:|::|:|:|.|.||....|
Zfish   245 PDIWSMGLSLVEMAIGRFPIPPPDAKELEQIFGQPLEGDPSASDTSPKPRPPGRPGSSYGPDSRP 309

  Fly   331 --SVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETS 393
              ::||.|..:|...||:|.:.     |..||.||||.||||..::|....:|:...||:..|..
Zfish   310 PMAIFELLDYIVNEPPPKLPSI-----FGAEFQDFVNKCLIKNPAERADLKQLMVHSFIKDSEAE 369

  Fly   394 HTDVAVYVADILESMEKDGITQ 415
            ..|.|.::...:      |:.|
Zfish   370 EVDFAGWLCSTI------GLNQ 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	119/333 (36%)
		S_TKc	123..387	CDD:214567	112/307 (36%)
map2k1	NP_998584.2	PKc_MEK1	63..382	CDD:270816	120/346 (35%)
		S_TKc	69..363	CDD:214567	112/308 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950