DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and Map2k4

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_038941354.1	Gene:	Map2k4 / 287398	RGDID:	1307040	Length:	408	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	231/400 - (57%)
Similarity:	278/400 - (69%)	Gaps:	33/400 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PSSTSSTSSGSTSSG----------SSSSSQHNHVTRCFGAQQPQQ-------TPPVASS---QV 78
            ||....:..|..:.|          :.||.|...:..|..||..::       .|||.|:   .:
  Rat     6 PSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGFQINFCEKAQSKRKALKLNFANPPVKSTARFTL 70

  Fly    79 PPVPAASSSSAADRHRERIRQ---QACGKLQFGEGGANTH-TFTSDDLEDEGEIGRGAFGAVNKM 139
            .|    :::...:.|.||:|.   ::.|||:.   ....| .||::||:|.|||||||:|:||||
  Rat    71 NP----NTTGVQNPHIERLRTHSIESSGKLKI---SPEQHWDFTAEDLKDLGEIGRGAYGSVNKM 128

  Fly   140 TFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTS 204
            ..|...::||||||||||||||||||||||:|||:|::|.||||||||||:|||||||||||.||
  Rat   129 VHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS 193

  Fly   205 LDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFG 269
            .||||||:|......|||.||.|||:|||.|||:|||.|||||||:|||||||.|.|:|||||||
  Rat   194 FDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFG 258

  Fly   270 ISGQLVDSIAKTKDAGCRPYMAPERIDPERAK-GYDVRSDVWSLGITLMEVATGNFPYRKWDSVF 333
            ||||||||||||:|||||||||||||||..:: |||||||||||||||.|:|||.|||.||:|||
  Rat   259 ISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVF 323

  Fly   334 EQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVA 398
            :||.|||:|:||:|..| ...|||..|::|||.||.|.||.||||..||:.|||...|....:||
  Rat   324 DQLTQVVKGDPPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVA 387

  Fly   399 VYVADILESM 408
            .||..||:.|
  Rat   388 CYVCKILDQM 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	206/291 (71%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	194/264 (73%)
Map2k4	XP_038941354.1	PKc_MKK4	104..394	CDD:270790	205/290 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353211
Domainoid	1	1.000	395	1.000	Domainoid score	I734
eggNOG	1	0.900	-	-		E1_KOG1006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48159
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1750
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	1	1.000	-	-		oto95948
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	O	PTHR48013
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3433
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770