DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and STK39

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_037365.2	Gene:	STK39 / 27347	HGNCID:	17717	Length:	545	Species:	Homo sapiens

Alignment Length:	353	Identity:	105/353 - (29%)
Similarity:	166/353 - (47%)	Gaps:	49/353 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QQPQQTPPV--------ASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDD 121
            |.|||..||        |::...|.|||   .||.........||.|           .....|.
Human    12 QLPQQAAPVTAAAAAAPAAATAAPAPAA---PAAPAPAPAPAAQAVG-----------WPICRDA 62

  Fly   122 LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIY--IVQF 184
            .|.:..||.||...|.....|...:.:|:|||.....:....:||.:::.:   ::|.:  :|.:
Human    63 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAM---SQCSHPNVVTY 124

  Fly   185 YGALFKEGDCWICMELMD--TSLDKFYKYIYEKQQRH---IPESILAKITVATVNALNYLKEELK 244
            |.:...:.:.|:.|:|:.  :.|| ..|||..:.:..   :.|:|:|.|....:..|:||....:
Human   125 YTSFVVKDELWLVMKLLSGGSMLD-IIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQ 188

  Fly   245 IIHRDVKPSNILLHRRGDIKLCDFGISGQLV-------DSIAKTKDAGCRPYMAPERIDPERAKG 302
             ||||:|..||||...|.:::.|||:|..|.       :.:.|| ..|...:||||.:  |:.:|
Human   189 -IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKT-FVGTPCWMAPEVM--EQVRG 249

  Fly   303 YDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGME----FSKEFVDF 363
            ||.::|:||.|||.:|:|||..||.|:..: :.|...:|.:||.|.|.....|    :.|.|...
Human   250 YDFKADMWSFGITAIELATGAAPYHKYPPM-KVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKL 313

  Fly   364 VNTCLIKKESDRPKYSRLLEMPFIRRGE 391
            ::.||.|..|.||..:.||:..|.::.:
Human   314 LSLCLQKDPSKRPTAAELLKCKFFQKAK 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	89/295 (30%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	87/281 (31%)
STK39	NP_037365.2	STKc_OSR1_SPAK	61..337	CDD:270787	88/284 (31%)
		S_TKc	63..337	CDD:214567	87/282 (31%)
		Interaction with RELT. /evidence=ECO:0000250\|UniProtKB:Q9Z1W9	310..536		10/32 (31%)
		Nuclear localization signal. /evidence=ECO:0000255	360..366
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..423
		Caspase cleavage related site	387..391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920