Protein Alignment Mkk4 and Map2k2

DIOPT Version :10

• Sequence 1: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_075627.2
• Gene: Map2k2 / 26396
• MGIID: 1346867
• Length: 401
• Species: Mus musculus
• Alignment Length: 394
• Identity: 130/394 - (32%)
• Similarity: 193/394 - (48%)
• Gaps: 80/394 - (20%)

  Fly    71 PPVASSQVPPVPAASSSSAAD------------RHRERIRQQACGKLQFGEGGANTHTFTSDDLE 123
            |.:|....|....||.::..|            :.|:|:......|.:.||       ...||.|
Mouse    16 PTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGE-------LKDDDFE 73

  Fly   124 DEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGAL 188
            ...|:|.|..|.|.|...:....:||.|.|...:....:.|::.:|:|:.:.|. .|||.||||.
Mouse    74 RISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNS-PYIVGFYGAF 137

  Fly   189 FKEGDCWICMELMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKP 252
            :.:|:..||||.|| .|||:..     |:.:.|||.||.|:::|.:..|.||:|:.:|:||||||
Mouse   138 YSDGEISICMEHMDGGSLDQVL-----KEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKP 197

  Fly   253 SNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLM 317
            ||||::.||:|||||||:||||:||:|.: ..|.|.||:|||:   :...|.|:||:||:|::|:
Mouse   198 SNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL---QGTHYSVQSDIWSMGLSLV 258

  Fly   318 EVATGNFPYRKWD----------------------------------------------SVFEQL 336
            |:|.|.:|....|                                              ::||.|
Mouse   259 ELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELL 323

  Fly   337 CQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYV 401
            ..:|...||:|.:..    ||.:|.:|||.||||..::|.....|:...||:|.|....|.|.::
Mouse   324 DYIVNEPPPKLPSGV----FSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWL 384

  Fly   402 ADIL 405
            ...|
Mouse   385 CRTL 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	118/336 (35%)
Map2k2	NP_075627.2	PKc_MEK	70..388	CDD:132946	118/331 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..310		0/27 (0%)