DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mkk4 and Map2k1

DIOPT Version :9

Sequence 1:NP_001163551.1 Gene:Mkk4 / 41020 FlyBaseID:FBgn0024326 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_032953.1 Gene:Map2k1 / 26395 MGIID:1346866 Length:393 Species:Mus musculus


Alignment Length:418 Identity:138/418 - (33%)
Similarity:207/418 - (49%) Gaps:87/418 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 PQQTP-PVASSQVPPVPAASSSSAA-----------------DRHRERIRQQACGKLQFGEGGAN 113
            |::.| |:..:..|...|.:.:|:|                 ::.|:|:......|.:.||    
Mouse     2 PKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGE---- 62

  Fly   114 THTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNEC 178
               ...||.|...|:|.|..|.|.|::.|....|||.|.|...:....:.|::.:|:|:.:.|. 
Mouse    63 ---LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS- 123

  Fly   179 IYIVQFYGALFKEGDCWICMELMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEE 242
            .|||.||||.:.:|:..||||.|| .|||:..     |:...|||.||.|:::|.:..|.||:|:
Mouse   124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-----KKAGRIPEQILGKVSIAVIKGLTYLREK 183

  Fly   243 LKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRS 307
            .||:||||||||||::.||:|||||||:||||:||:|.: ..|.|.||:|||:   :...|.|:|
Mouse   184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERL---QGTHYSVQS 244

  Fly   308 DVWSLGITLMEVATGNFPYRKWD-----------------------------------------S 331
            |:||:|::|:|:|.|.:|....|                                         :
Mouse   245 DIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMA 309

  Fly   332 VFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTD 396
            :||.|..:|...||:|.:..    ||.||.||||.||||..::|....:|:...||:|.:....|
Mouse   310 IFELLDYIVNEPPPKLPSGV----FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVD 370

  Fly   397 VAVYVADILESMEKDGITQFTANQQAES 424
            .|.::...:      |:.|.:....|.|
Mouse   371 FAGWLCSTI------GLNQPSTPTHAAS 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mkk4NP_001163551.1 PKc_MKK4 115..405 CDD:270790 122/331 (37%)
S_TKc 123..387 CDD:214567 115/305 (38%)
Map2k1NP_032953.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 6/24 (25%)
PKc_MEK1 62..380 CDD:270816 123/344 (36%)
RAF1-binding. /evidence=ECO:0000250 270..307 0/36 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D688282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2221
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.950

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