DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and mkk-4

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_509682.1	Gene:	mkk-4 / 185682	WormBaseID:	WBGene00003368	Length:	363	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	164/369 - (44%)
Similarity:	227/369 - (61%)	Gaps:	44/369 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DQLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQTPPVASSQVPPVPAAS 85
            |:...|::|:|  |:|.|:..:..:.:|:                  ::|.|..|.
Worm     6 DENLRNSMSLR--PTSLSTRPTSLSVNGN------------------EKTLPEESV--------- 41

  Fly    86 SSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAV 150
                       :|..:.|.|::.: ..:.:||:|.:|:|.|.||.|.||.|.||..|:..|::||
Worm    42 -----------LRSLSTGTLKYPD-DEHLYTFSSANLQDLGAIGNGNFGTVYKMRHKETGKLIAV 94

  Fly   151 KRIR-STVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYE 214
            |||| :.:..:||.:||.:.:.::||.:...||:||||:|.||||||||||||.|:|..||.:|.
Worm    95 KRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYM 159

  Fly   215 KQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIA 279
            .:...:.|:::..|||.||:||:|||:|||||||||||||||:...|.:|||||||.|||.:|.|
Worm   160 VKNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFA 224

  Fly   280 KTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEP 344
            ||.||||:||:|||||  ..:..||||||||||||||.|:|||.|||::|:|:|:|:..||.|:|
Worm   225 KTHDAGCQPYLAPERI--TSSDKYDVRSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVSGDP 287

  Fly   345 PRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIR 388
            |.|....:...:|...|.|:||||.|....||||..|....|.|
Worm   288 PILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFYR 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	150/275 (55%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	144/264 (55%)
mkk-4	NP_509682.1	PKc_MKK4	59..347	CDD:270790	150/275 (55%)
mkk-4	NP_509682.1	S_TKc	72..329	CDD:214567	142/258 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166761
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1006
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I1612
Isobase	1	0.950	-	0	Normalized mean entropy	S1132
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	1	1.000	-	-		otm14198
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X3433
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.750