Protein Alignment Mkk4 and mek-2

DIOPT Version :9

• Sequence 1: NP_001163551.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_491087.1
• Gene: mek-2 / 171872
• WormBaseID: WBGene00003186
• Length: 387
• Species: Caenorhabditis elegans
• Alignment Length: 429
• Identity: 137/429 - (31%)
• Similarity: 197/429 - (45%)
• Gaps: 95/429 - (22%)

  Fly    13 SSRSRNPPDQLSLNNLSIRHPPSSTSSTSSG-STSSGSSSSSQHNHVTRCFGAQQPQQTPPVASS 76
            |.:.|||        |.:..||:....:.|| :|:..::::.......:..|..:||
 Worm     3 SGKRRNP--------LGLSLPPTVNEQSESGEATAEEATATVPLEEQLKKLGLTEPQ-------- 51

  Fly    77 QVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMTF 141
                                 .|:....||..||   ....:.|.|:.|||:|.|..|.|||...
 Worm    52 ---------------------TQRLSEFLQVKEG---IKELSEDMLQTEGELGHGNGGVVNKCVH 92

  Fly   142 KKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMD-TSL 205
            :|...:||.|.:...:....::|::.:|.|:.|.|. .:||.||||.....|..||||.|| .||
 Worm    93 RKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNS-PFIVGFYGAFVDNNDISICMEYMDGLSL 156

  Fly   206 DKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGI 270
            |     |..|:...:||..:.:|:||.|..|.|||:|:||:||||||||:|::..|:|||||||:
 Worm   157 D-----IVLKKVGRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGV 216

  Fly   271 SGQLVDSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGNFP--------YR 327
            ||.|:||:|.: ..|.|.||||||:   ....|.:.||:||.|::|:|:..|.:|        |.
 Worm   217 SGMLIDSMANS-FVGTRSYMAPERL---TGSHYTISSDIWSFGLSLVELLIGRYPVPAPSQAEYA 277

  Fly   328 KW-----------DS----------------VFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVN 365
            ..           ||                :||.|..:|.|.||.|...:    |:.|.:.||:
 Worm   278 TMFNVAENEIELADSLEEPNYHPPSNPASMAIFEMLDYIVNGPPPTLPKRF----FTDEVIGFVS 338

  Fly   366 TCLIKKESDRPKYSRLLEMPFIRRGETSHTD---VAVYV 401
            .||.|..|:|.....|....|..: ...|.|   .||:|
 Worm   339 KCLRKLPSERATLKSLTADVFFTQ-YADHDDQGEFAVFV 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	119/326 (37%)
		S_TKc	123..387	CDD:214567	111/299 (37%)
mek-2	NP_491087.1	PKc_MEK	71..380	CDD:132946	119/321 (37%)
		S_TKc	74..360	CDD:214567	111/299 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950