DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkk4 and stk39

DIOPT Version :9

Sequence 1:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_017953089.2	Gene:	stk39 / 100488948	XenbaseID:	XB-GENE-1012528	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	397	Identity:	112/397 - (28%)
Similarity:	176/397 - (44%)	Gaps:	84/397 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SSRSRNPPDQLSLNNLSIRHPPSSTSSTSSGSTSSGSSSSSQHNHVTRCFGAQQPQQTPPVASSQ 77
            ||.|.|.|.:.|:                  ||:|.|.|:.          .||.|...|:.|
Frog    76 SSHSSNKPRRRSI------------------STTSLSMSAE----------PQQQQSDSPLHS-- 110

  Fly    78 VPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMTFK 142
             |..|||          :.|....|                .|..|.:..||.||...|.....|
Frog   111 -PQPPAA----------QPIGWPIC----------------RDSYELQEVIGSGATAVVQAALCK 148

  Fly   143 KLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIY--IVQFYGALFKEGDCWICMELMD--T 203
            ...:.:|:|||.....:....:||.:::.:   ::|.:  ||.:|.:...:.:.|:.|:|:.  :
Frog   149 PRQERVAIKRINLEKCQTSMDELLKEIQAM---SQCSHPNIVTYYTSFVVKEELWLVMKLLSGGS 210

  Fly   204 SLDKFYKYIY---EKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKL 265
            .|| ..|::.   |.:...:.|||:|.|....:..|:||....: ||||:|..||||...|.:::
Frog   211 MLD-IIKHVVGRGEHKNGVLEESIIATILKEVLEGLDYLHRNGQ-IHRDLKAGNILLGEDGSVQI 273

  Fly   266 CDFGISGQLV-------DSIAKTKDAGCRPYMAPERIDPERAKGYDVRSDVWSLGITLMEVATGN 323
            .|||:|..|.       :.:.|| ..|...:||||.:  |:.:|||.::|:||.|||.:|:|||.
Frog   274 ADFGVSSFLATGGDVTRNKVRKT-FVGTPCWMAPEVM--EQVRGYDFKADMWSFGITAIELATGA 335

  Fly   324 FPYRKWDSVFEQLCQVVQGEPPRLLTSYNGME----FSKEFVDFVNTCLIKKESDRPKYSRLLEM 384
            .||.|:..: :.|...:|.:||.|.|.....|    :.|.|...::.||.|..|.||..:.||:.
Frog   336 APYHKYPPM-KVLMLTLQNDPPTLETGVEDKEMMRKYGKSFRKLISLCLQKDPSKRPTAAELLKC 399

  Fly   385 PFIRRGE 391
            .|.::.:
Frog   400 KFFQKSK 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	90/295 (31%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	88/281 (31%)
stk39	XP_017953089.2	STKc_OSR1_SPAK	126..402	CDD:270787	89/284 (31%)
stk39	XP_017953089.2	OSR1_C	516..573	CDD:403428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920