DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	535	Identity:	143/535 - (26%)
Similarity:	249/535 - (46%)	Gaps:	74/535 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASIILSGWLL---LAWLYFLWS------------RRRYYKVAWQLRGPIGWPLIGMGLQMMNP 50
            :|..::.:.|||   |||.|..:.            ||.::   |..:|            |:||
Human    20 LLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF---WGHQG------------MVNP 69

  Fly    51 -ETFLQYMDGLSRQFKAPFISWMG-TSCFLYINDPHSVEQILNSTHCTNKGD--FYRFMSSAIGD 111
             |..::.:..|...:...|..||| .|..|.:..|..:..::|::......|  ||.|:...:||
Human    70 TEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGD 134

  Fly   112 GLFTSSSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIV 176
            ||..|:..:|.:|||::.|||...||..::.|||....::..|.:|...:....|::::.:..:.
Human   135 GLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMT 199

  Fly   177 LEAACQTTMGKKMNFQHDGSLCIFK------AYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQ 235
            |::.      :|..|..| |.|..|      |...|:.:..||.....|:.|.:|..:...:..:
Human   200 LDSL------QKCVFSFD-SHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFR 257

  Fly   236 KVVGILFGFIEQLLEPIVSVVAANSNPDQQRSE-MEMRGKSKAI-FIE--QVREHVERGQLSWQD 296
            :...::..|.:.:::.     ...:.|.|...: ::.:.|||.: ||:  .:.:..:..:||.:|
Human   258 RACRLVHDFTDAVIQE-----RRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDED 317

  Fly   297 VRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLH---KELVTELPPSGDINLEQLQRLEYT 358
            :|.||:..:....:||::.|.:.:..||.||.|||:..   :||:.:..|. :|..:.|..|.:.
Human   318 IRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPK-EIEWDDLAHLPFL 381

  Fly   359 EMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNP 423
            .|.:.|::||..|||::.|...|||.|.  ||. :||:|....|.::....:..|| |....|:|
Human   382 TMCMKESLRLHPPVPVISRHVTQDIVLP--DGR-VIPKGIICLISVFGTHHNPAVW-PDPEVYDP 442

  Fly   424 DAHFGLDS---PQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRI---STEARLE-EL 481
               |..|.   .:|...||:||:.|.|.|||..:|...||::||.....:|:   .||.|.: ||
Human   443 ---FRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPEL 504

  Fly   482 LVKGNISLKLKDYPL 496
            :::....|.|:..||
Human   505 VLRAEGGLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	123/463 (27%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	8/36 (22%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	132/497 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920