Protein Alignment Cyp313b1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_649807.1
• Gene: Cyp313b1 / 41019
• FlyBaseID: FBgn0037601
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 127/582 - (21%)
• Similarity: 218/582 - (37%)
• Gaps: 161/582 - (27%)

  Fly     2 LASIILSGWL--LLAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQMMNPETFLQYMDGLSRQF 64
            :.::.||..|  ||.| |...:..|..|:.  ||.|...|.|| .|.......:...|:  .|:.
Human    15 MVTVALSVALLALLKW-YSTSAFSRLEKLG--LRHPKPSPFIG-NLTFFRQGFWESQME--LRKL 73

  Fly    65 KAPFIS-WMGTSCFLYINDPHSVEQIL--NSTHCTNKGDFYRFMSS-----AIGDGLFTSSSPRW 121
            ..|... ::|...|:.|::|..::|:|  |.::.||:      |:|     ::.|.:......||
Human    74 YGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR------MASGLEFKSVADSVLFLRDKRW 132

  Fly   122 HKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGK---------RLE----IYQILK 173
            .:.|..:..||..:.|:        |..:|:.:..::|...|:         ||.    ||..|.
Human   133 EEVRGALMSAFSPEKLN--------ELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLH 189

  Fly   174 KIVL--------EAACQTTMGKKMNFQHDG-SLCIFKAYNGLT---------------------- 207
            ...|        ..||...:.....:...| :..|.:.|...|
Human   190 YATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDP 254

  Fly   208 ---------EVCVKRMLSPWL--YPDLIYRRSGLFRLQQKVVGILFGFIEQLLEPIVSVVAANSN 261
                     |.|:.|.:...|  :|.::...:.:  |..|....|.||..:|:..::::
Human   255 FVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARI--LPNKNRDELNGFFNKLIRNVIAL------ 311

  Fly   262 PDQQRSEMEMRGKSKAIFIEQV--------------------------------REHVERGQ--- 291
            .|||.:|...|.     |::.|                                |:|.....
Human   312 RDQQAAEERRRD-----FLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARP 371

  Fly   292 LSWQDVRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDI--------- 347
            |:..::..:|.:.:.|.:|..:..|.|....||.:|..||||.:|:        |:
Human   372 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV--------DVFKEKHMAPE 428

  Fly   348 --NLEQLQRLEYTEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRD 410
              :||  :.|.|.:|||.|.:|::.|.....|.|.||.::.   |: .||.|..:.:.:..:..|
Human   429 FCSLE--EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL---GQ-RIPAGAVLEMAVGALHHD 487

  Fly   411 ERVWGPLSRTYNPDAHFGLDSPQRH-AFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYR 471
            ...| |...|:||: .|..::.|:| .|.::||..|.|.|:|.|...:.:||.|..:...:|
Human   488 PEHW-PSPETFNPE-RFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_649807.1	CYP313-like	66..498	CDD:410680	109/516 (21%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	109/518 (21%)