DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	535	Identity:	143/535 - (26%)
Similarity:	243/535 - (45%)	Gaps:	74/535 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASIILSGWLL---LAWLYFLWSRRRYY-------KVAWQLRGPIGWPLIGMGLQMMNP-ETFL 54
            :|..:::..|||   |||.|..::..|..       |..|      .|..:|    ::.| |..|
Human    20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNW------FWGHLG----LITPTEEGL 74

  Fly    55 QYMDGLSRQFKAPFISWMGTSC-FLYINDPHSVEQILNSTHCTNKGD--FYRFMSSAIGDGLFTS 116
            :....:|..:...|..|:|... |:.:..|.::..|.|::......|  |.||:...:|:|:..|
Human    75 KNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLS 139

  Fly   117 SSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAAC 181
            ...:|.:|||::.|||...||.:::.|||..|.::|.|.:....:...||::::.:..:.|::.
Human   140 GGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSL- 203

  Fly   182 QTTMGKKMNFQHDGSLC------IFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGI 240
                 :|..|..| |.|      .......|:.:..||......:.|.:|..|...|...:...:
Human   204 -----QKCIFSFD-SHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRL 262

  Fly   241 LFGFIEQLLEPIVSVVAANSNPDQQRSEMEMRG---------KSKAI-FIE-QVREHVERGQ-LS 293
            :..|.:.::.             ::|..:..:|         |||.: ||: .:....|.|: ||
Human   263 VHDFTDAVIR-------------ERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALS 314

  Fly   294 WQDVRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLH---KELVTELPPSGDINLEQLQRL 355
            .:|:|.||:..:....:||::.|.:.:..||.||.|||:..   :||:.:..|. :|..:.|.:|
Human   315 DEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPK-EIEWDDLAQL 378

  Fly   356 EYTEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRT 420
            .:..|.:.|::||..|.|.:.|...|||.|.  ||. :||:|....|||..:..:..|| |....
Human   379 PFLTMCVKESLRLHPPAPFISRCCTQDIVLP--DGR-VIPKGITCLIDIIGVHHNPTVW-PDPEV 439

  Fly   421 YNPDAHFGLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRI---STEARLE-EL 481
            |:|......:|..|...||:||:.|.|.|||..:|...||::||.:...:|.   .||.|.: ||
Human   440 YDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLEL 504

  Fly   482 LVKGNISLKLKDYPL 496
            :::....|.|:..||
Human   505 IMRAEGGLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	123/468 (26%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	130/488 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920