DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	148/529 - (27%)
Similarity:	246/529 - (46%)	Gaps:	66/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SIILSG--WLLLAWLYFLWSRRRYYKVAWQLRG-----PIGWPLIGMGLQMMNP-ETFLQYMDGL 60
            :::|.|  |:|...|..:::..|.::   :|||     ...|.:..:|  |:.| |..|:.:..|
  Rat    21 TLLLFGASWILAQILTQIYAAYRNFR---RLRGFPQPPKRNWLMGHVG--MVTPTEQGLKELTRL 80

  Fly    61 SRQFKAPFISWMG------TSCFLYINDPHS--VEQILNSTHCTNKGD--FYRFMSSAIGDGLFT 115
            ...:...|:.|:|      |.|       ||  |..|||::......|  ||..:...:||||..
  Rat    81 VGTYPQGFLMWIGPMVPVITLC-------HSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLV 138

  Fly   116 SSSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAA 180
            |:..:|.:|||::.|||...||..::.|||....::..|.:....:...||::::.:..:.|::.
  Rat   139 SAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLMTLDSL 203

  Fly   181 CQTTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFI 245
            .:.......|.|...|..| .|...|:.:..||...|.|:.||:|..:.......|...::..|.
  Rat   204 QKCVFSFDSNCQEKSSEYI-AAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKACNLVHEFT 267

  Fly   246 EQLLEPIVSVVAANSNPDQQRSE-MEMRGKSKAI-FIE--QVREHVERGQLSWQDVRDEANVTIA 306
            :.::..     ...:.|||...| ::.:.|||.: ||:  .:.:..:..:||.:|:|.||:..:.
  Rat   268 DAVIRE-----RRRTLPDQGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMF 327

  Fly   307 ATFETTSTALYFTILCLAMHPCYQEKLH---KELVTELPPSGDINLEQLQRLEYTEMVINEAMRL 368
            ...:||::.|.:.:..||.||.|||:..   :||:.:..|. :|..:.|.:|.:..|.|.|::||
  Rat   328 EGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDPE-EIEWDDLAQLPFLTMCIKESLRL 391

  Fly   369 FAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLD--- 430
            ..||.::.|...|||.|.  ||. .||:|....|.|:.:..:..|| |....|||   |..|
  Rat   392 HPPVTVISRCCTQDILLP--DGR-TIPKGIICLISIFGIHHNPSVW-PDPEVYNP---FRFDPEN 449

  Fly   431 ----SPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTE----ARLEELLVKGNI 487
                ||    .||:||:.|.|.|||..:|...||:.||.....:|:..:    .|..||:::...
  Rat   450 IKDSSP----LAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEG 510

  Fly   488 SLKLKDYPL 496
            .|.|:..||
  Rat   511 GLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	134/470 (29%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	131/465 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920