DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	519	Identity:	139/519 - (26%)
Similarity:	255/519 - (49%)	Gaps:	30/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASIILSGWLLLAWLYFLWSRRRY-----YKVAWQLRGPI-----GWPLIGMGLQMMN--PETF 53
            :|..:.:.|.|..|.|..|.:...|     |...|....||     .:|:||..||...  .:.|
Zfish     3 ILFGLYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAGDFF 67

  Fly    54 LQYMDGLSRQFKAPFIS-WMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSS 117
            .|.::|.:.....|... |:|...||.:....::|.:|:::...:|...|||:...:|.||.||:
Zfish    68 NQIIEGTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTST 132

  Fly   118 SPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQ 182
            ..:|...|:::.|.|...|||:||.:.|.:.::|:||  ::.::.|:....:..:....|:..|:
Zfish   133 GEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQK--MQKLEDGEPFNCFNFITLCALDIICE 195

  Fly   183 TTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQ 247
            |.||||:..|.:......::...::::..||..:|||:||.||.:....:...|.:.||..|...
Zfish   196 TAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFTAN 260

  Fly   248 LLEPIVSVVAANSNPDQQRSEMEMRGKSKAIFIEQ-VREHVERGQ-LSWQDVRDEANVTIAATFE 310
            ::......:::..:.|..:.|     :.:..|::. ::...|.|| ||.:|:::|.:..:....:
Zfish   261 VIRERAEFMSSEPDSDSDQGE-----RKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHD 320

  Fly   311 TTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGD--INLEQLQRLEYTEMVINEAMRLFAPVP 373
            ||:.::.:.:..:..||..|:.:..|| .|:..|.:  :.:|.|::|.|.|.||.|::|:|..||
Zfish   321 TTAASMNWALHLIGSHPEVQKAVQAEL-QEVFGSSERHVGVEDLKKLRYLECVIKESLRIFPSVP 384

  Fly   374 MVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFA 438
            :..||..:...:    ..|.:|:|....|..|.:.||.|.: |....:.|:.....:|..||.:|
Zfish   385 LFARSICEACHI----NGFKVPKGVNAVIIPYALHRDPRYF-PEPEEFQPERFMPENSKGRHPYA 444

  Fly   439 FVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLKLKDYPLCRVERR 502
            ::||:.|.|.|||.|:|.|..|::||.|.|.:.:......|||...|.:.|:.:.....:::||
Zfish   445 YIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGIWIKLQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	123/452 (27%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	126/473 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920