DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	125/535 - (23%)
Similarity:	251/535 - (46%)	Gaps:	61/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IILSGWLLL---AWLYFLWSRRRYYKV--------------AWQLRGPI--GWPLIGMGLQMMNP 50
            |||  ||:|   |.||:|....:.|.:              ..::..||  |..:.|..|.:...
  Fly     2 IIL--WLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGR 64

  Fly    51 E--TFLQYMDGLSRQFKAPFISWMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGL 113
            :  ....|....:::....:|.::.......|.|..|.|.:||..:...||..|.|:...:..||
  Fly    65 DHAGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLRTGL 129

  Fly   114 FTSSSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLE 178
            .||:..:||..|:::.|.|...||:.|..||..|::..|  |:.|| |....:.::.::.:..|.
  Fly   130 LTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFL--LQFEG-QDEVTITLHDVIPRFTLN 191

  Fly   179 AACQTTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQ--KVVGIL 241
            :.|:|.||.|::...:......:.::.:.|..::|:.:|.|:.|.::.   :|..:.  ..:.::
  Fly   192 SICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFE---MFAAKDFASALDVV 253

  Fly   242 FGFIEQ-------LLEPIVSVVAANSNPDQQRSEMEMRGKSKAIFIEQ--VREHVERGQLSWQDV 297
            ..|..:       ||:..:...::.::.|...|:.........|:.|:  :.:|:        .:
  Fly   254 HRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTLIYAEKDGLIDHI--------GI 310

  Fly   298 RDEANVTIAATFETTSTALYFTILCLAMHP-----CYQEKLHKELVTELPPSGDINLEQLQRLEY 357
            .:|.:..:...::|||..|.|.::.::::|     |||| :.:.:..:|   .::::.||.:|:|
  Fly   311 CEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQE-IQEHIDDDL---SNLDVGQLNKLKY 371

  Fly   358 TEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYN 422
            .|..:.|..|||..||::.|.|.|:.:|..|   .::|:|.||.|.::::.|:.:.|.. ...:.
  Fly   372 LEYFMKETTRLFPSVPIMGREAVQETELANG---LILPKGAQITIHVFDIHRNAKYWDS-PEEFR 432

  Fly   423 PDAHFGLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNI 487
            |:.....:...||.:|:|||:.|.|.|||.:||...||.|:..:.:.:::......::::....|
  Fly   433 PERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHTGI 497

  Fly   488 SLKLKDYPLCRVERR 502
            :|:.:|....::.||
  Fly   498 TLRTQDKIRVKLVRR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	109/460 (24%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	109/476 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.970