DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	165/516 - (31%)
Similarity:	272/516 - (52%)	Gaps:	54/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLA-----WLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQMMNPETFLQYMDGLS------RQF 64
            ||||     |:||||||||.|.:..::.||||.|::|..|     |..:.|...||      .::
  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSL-----ENIITYKRKLSFRTKYLNKY 65

  Fly    65 KAPFISWMGTSCFLYINDPHSVEQILNSTHCTNKGD-FYRFMSSAIGDGLFTSSSPRWHKHRRLI 128
            .:..::|||...|:...||..||.|.:|..|.||.. ....::|.:|:||.....|.|...|:..
  Fly    66 GSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKHF 130

  Fly   129 NPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMGKKMNFQH 193
            ||:|.:.:|.:|..||:||.:||:..|:.. |..|: :::...:.:...:.|.|||||.::  :|
  Fly   131 NPSFKQDLLLSFFHIFDAETKVLMNLLDTY-VDKGE-IDVVPEMLRWSFKIAAQTTMGSEV--KH 191

  Fly   194 D-----GSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLLEPIV 253
            |     |||  .:::..|.......:|.|.:...:|.:..|..:|:..    .|..|:::|:.:|
  Fly   192 DEHFKNGSL--VESFESLISHSTLNILMPLVQNRMISKICGYDKLRAD----NFSRIQKMLDNVV 250

  Fly   254 S-----VVAANSNPDQQRSEMEMRGKSKAIFIEQVREHVERGQLSWQDVRDEANVTIAATFETTS 313
            :     :...:|:|:..            |.|.:..|...:|.:::.||:.|..:.|||.::|::
  Fly   251 NKKVNPLPKTDSDPESN------------IVINRAMELYRKGDITYMDVKSECCIMIAAGYDTSA 303

  Fly   314 TALYFTILCLAMHPCYQEKLHKELVTELPPSG--DINLEQLQRLEYTEMVINEAMRLFAPVPMVL 376
            ..:|..:..||.||.:||.:.:||....|.:|  .|....:|:|:|.|.||.|.:||...:|:..
  Fly   304 LTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPITA 368

  Fly   377 RSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFVP 441
            |....|::|..|   .|||:|..||||:::..|:..||||.:..:|||.....:..|:|.:|::|
  Fly   369 RETKNDVRLSNG---VLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIP 430

  Fly   442 FTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLKLKDYPLCRVERR 502
            |.:|.|.|||.:||.|..|..|.||.|:|:|||....::|:...|:::||.:||..:::||
  Fly   431 FARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMKLAEYPRLKLQRR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	141/459 (31%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	141/459 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450082
Domainoid	1	1.000	169	1.000	Domainoid score	I1170
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	1	0.950	-	0	Normalized mean entropy	S4824
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D28972at7147
OrthoFinder	1	1.000	-	-		FOG0008559
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.950