DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp313a2

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	157/516 - (30%)
Similarity:	261/516 - (50%)	Gaps:	39/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASIILSGWLLLAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQ-------MMNPETFLQYMD 58
            |:...:|....|:.|:.||||||:.|.:..||.|.:|.||:|..::       .|:..|  .|||
  Fly     1 MIVIQLLIAASLILWIRFLWSRRKLYMLMMQLPGRMGLPLLGNSVRYLIISRGRMSSRT--TYMD 63

  Fly    59 GLSRQFKAPFISWMGTSCFLYINDPHSVEQILNSTHCTNK-GDFYRFMSSAIGDGLFTSSSPRWH 122
                :..:.:::|:||:..:...||...|::|.|..|.|: ......::.::|.||.|....:|.
  Fly    64 ----KHGSTYMAWIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALSMGYGLLTLQGSKWM 124

  Fly   123 KHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMG- 186
            ..|:.:||||...:|.:||||||||.::|:...: ..|..|:: ::...|.:.....|.|||:|
  Fly   125 ARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFD-SFVGQGEK-DVLSDLIRWSFAIATQTTLGT 187

  Fly   187 ---KKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQL 248
               |..||::|   .|.|.|..:..:.:..:..|::...::.:..||..|:::....:...|..:
  Fly   188 DVTKDDNFEND---AILKTYQSMLRLTIINIFVPFVQNKIVSKLFGLEWLRRRDASAINKMINNI 249

  Fly   249 LEPIVSVVAANSNPDQQRSEMEMRGKSKAIFIEQVREHVERGQLSWQDVRDEANVTIAATFETTS 313
            |:.     ..||||:.. .|.|::     ..|.:..|.....::|..::..|.:..:.|.|||::
  Fly   250 LDK-----KLNSNPENY-CESELK-----TVIHRAIELFRNDEMSLMELGAECSSMVLAAFETSA 303

  Fly   314 TALYFTILCLAMHPCYQEKLHKELVTELPPSGDINL--EQLQRLEYTEMVINEAMRLFAPVPMVL 376
            ..:|:.::.|||.|.:||.:..|:....|.:..|.:  ..||:|.|.:.|:||.:||...||...
  Fly   304 HTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLRLMPSVPFSS 368

  Fly   377 RSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFVP 441
            |...:|::|..|   .:||:|..|.|||:|.||:...||..:..:||:.........||.:||:|
  Fly   369 RETLEDLRLSNG---VVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRHPYAFIP 430

  Fly   442 FTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLKLKDYPLCRVERR 502
            |:||.|.|||:||..|..||.|.:|.|:|::.|....|.|....::.:||...|....|||
  Fly   431 FSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFPYENLEFVDHMVIKLAQSPQLAFERR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	135/454 (30%)
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	135/454 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450078
Domainoid	1	1.000	169	1.000	Domainoid score	I1170
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D28972at7147
OrthoFinder	1	1.000	-	-		FOG0008559
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000