DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	125/519 - (24%)
Similarity:	256/519 - (49%)	Gaps:	45/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GWLLLA---WLYFLWSRR-RYYKVAWQLRGPIGWPLIG---MGLQMMNPETFLQYMDGLSRQF-- 64
            |.||||   :|.:::.|: |..::..:...|...|.||   :..:::.|....:..:.::...
  Fly     7 GLLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHD 71

  Fly    65 -KAPFISWMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHKHRRLI 128
             :|..  ||||..:|...:|..::.:.::.....|.:.||...:.:.:|||||...:|...|:::
  Fly    72 HRAKL--WMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSHRRKIV 134

  Fly   129 NPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMGKKMNFQH 193
            .|||...::..|:.:|..::.:||..: .:..:.|.:::..|::....|:..|:|.:|..:..|.
  Fly   135 MPAFNYTMIKQFVAVFEKQSRILLTNV-AKFAESGDQIDFLQLISCFTLDTICETALGVSVGSQS 198

  Fly   194 DGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLLEPIVSVVAA 258
            ........|...:..:..||:.:.:.....|::|:..::.:|:::..|.||.|.:::..:..:..
  Fly   199 SAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQ 263

  Fly   259 NS-NPDQQRSEMEMRGKSKAI-FIEQVREHVERG----QLSWQDVRDEANVTIAATFETTSTALY 317
            :: |.:.|.|:.|:.|..:.: |::.:.  :.:|    .|:.:|:|:|.:..|...|:.|:|.|.
  Fly   264 DAENRNYQSSDAELDGVKRTLCFLDTLL--LSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLN 326

  Fly   318 FTILCLAMHPCYQEKLHKEL--VTELPPSGDINLEQLQRLEYTEMVINEAMRLFAPVPMVLRSAD 380
            |.:..:.:||.:|::..:|:  |.....|..|::||:::||:.|..|.|.:|::...|:..|.|.
  Fly   327 FFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTARKAT 391

  Fly   381 QDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFVPFTKG 445
            .:..:    .:|.||:|:.:.|....|.|.:..: |....:.||.......|:..|..|:||..|
  Fly   392 ANCTI----NDFFIPKGSDVIISPIYMGRCKDFF-PDPMVFKPDRWAIGAEPKIEATTFIPFMAG 451

  Fly   446 LRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLKL---------KDYPLCRVE 500
            .|.|:|.|||.:::|::||.:.|::       |.|.|.:..:.|||         :.| |||.:
  Fly   452 ARSCMGQRYAMVMLKMVLAHLLRNF-------LFEPLGERQVKLKLNFVITLHTVEPY-LCRAK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	107/454 (24%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	115/487 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	4	3.960