DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	150/523 - (28%)
Similarity:	248/523 - (47%)	Gaps:	71/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASIILSGWLLLAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQMM---NPETFLQYMDGLSRQ 63
            |..::|.|   ..|:..|....|..||| .|.|||..|||| .:|:|   ||:||::    :.|:
  Fly     5 LLVVLLFG---AGWIIHLGQADRRRKVA-NLPGPICPPLIG-AMQLMLRLNPKTFIK----VGRE 60

  Fly    64 FKAPF----ISWMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHKH 124
            :...|    ..|:.....:...|....||:|:|.....|...|:.:...:|:||..|....||:.
  Fly    61 YVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQR 125

  Fly   125 RRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMGKKM 189
            |::|.|.|...||..|:.:|:.::.:.:|:|..:.  :|...::|:.:....|:...:|.||.|:
  Fly   126 RKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKA--NGNTFDVYRSICAAALDIIAETAMGTKI 188

  Fly   190 NFQHDGSLCIFKAYNGLTEVCVKRMLSPWL---------YPDLIYRRSGLFRLQQKVVGILFGFI 245
            ..|.:.|....:|.|..|.:...|.:|.:|         :|.|.:|::.|.|..|:....:....
  Fly   189 YAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKR 253

  Fly   246 EQLLEPIVSVVAANSNPDQQRSEMEMRGK---SK---AIFIEQVREHVERGQLSWQDVRDEANVT 304
            .|.||            |||...|:...:   ||   |:....:...|:...|:..::|:|.:..
  Fly   254 RQALE------------DQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTF 306

  Fly   305 IAATFETTSTALYFTILCLAMHPCYQEKLHKELVTEL--PPSGDINLEQLQRLEYTEMVINEAMR 367
            :....:||::||.|.:..|:.||..|.|:.:|:|..|  ..|..:::..|..|:|.|.||.|::|
  Fly   307 MFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLR 371

  Fly   368 LFAPVPMVLRSADQDIQLK---RGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGL 429
            ::.|||:|.|....|.:..   .|||  :||.|::|.|.|:.:.|....:.      |||...
  Fly   372 MYPPVPIVGRKLQTDFKYTHSVHGDG--VIPAGSEIIIGIFGVHRQPETFP------NPDEFI-- 426

  Fly   430 DSPQRH-------AFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNI 487
              |:||       .|..:||:.|.|.|||.::||:.||::||:|.|.|.:....:..|.:|  ||
  Fly   427 --PERHENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIV--NI 487

  Fly   488 SLK 490
            .|:
  Fly   488 VLR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	135/474 (28%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	125/453 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.970