DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313b1 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	536	Identity:	133/536 - (24%)
Similarity:	229/536 - (42%)	Gaps:	91/536 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASIILSGWLLLAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQMMNP----ETFLQYMDGLS 61
            :.|.|.|:  .||..:..|..||:..|...:..||....|.|...:....    |..:::|:  .
Zfish    16 VFALIFLA--CLLTVVKLLIVRRKGVKTMERFPGPPAHWLFGHVKEFRQDGHDLEKIVKWME--L 76

  Fly    62 RQFKAPFISWMGTS-CFLYINDPHSVEQILNSTHCTNKGDF-YRFMSSAIGDGLFTSSSPRWHKH 124
            .||..|.  |.|.| ..|.|:.|..|:.||.:|.  .|.|: |:|....:||||..|:..:|.:|
Zfish    77 YQFAFPL--WFGPSLAVLNIHHPSYVKTILTTTE--PKDDYAYKFFIPWLGDGLLVSTGQKWFRH 137

  Fly   125 RRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVL------------ 177
            |||:.|.|...:|..::.:.:...:|:|.|.|:    |.:..|.:::.|.:.|
Zfish   138 RRLLTPGFHYDVLKPYVKLISDSTKVMLDKWEV----HSRSEESFELFKHVSLMTLDSIMKCAFS 198

  Fly   178 -EAACQTTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQ------Q 235
             .:.|||..|.....|     .:|       ::|....|...::|   |....:|.|.      :
Zfish   199 CNSNCQTDSGTNPYIQ-----AVF-------DLCHLVNLRFRVFP---YHSKAIFHLSPHGYRFR 248

  Fly   236 KVVGILFGFIEQLLEPIVSVVAANSNPDQQRSEMEMRGKSKAI--------FIE---QVREHVER 289
            |...|......:::              ::|.|:....:.:.|        |::   ..|:..::
Zfish   249 KAASIAHNHTAEVI--------------RKRKEVLKMEEEQGIVKNRRYLDFLDILLSARDEHQQ 299

  Fly   290 GQLSWQDVRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQR 354
            | ||.:|:|.|.:..:....:||::.:.:....||.:|.:|||..:|:...|.....:..|.|.:
Zfish   300 G-LSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQALDGKATLEWEDLNK 363

  Fly   355 LEYTEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVW-GPLS 418
            :.||.|.|.|::||..|||.:.|...:.:..  .||. .:|.|..||:.||.:..:..|| .|..
Zfish   364 IPYTTMCIKESLRLHPPVPGISRKLTKPLTF--FDGR-TVPEGCTIGVSIYGIHMNSTVWENPYK 425

  Fly   419 RTYNPDAHFGLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRI-----STEARL 478
              ::|......:...|...|||||:.|.|.|||..:|...||:.:|...:.|.:     .|...:
Zfish   426 --FDPLRFLPENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRYYLIKDPDHTPKMI 488

  Fly   479 EELLVK--GNISLKLK 492
            .:::::  ..|.:|:|
Zfish   489 PQVVLRSLNGIHIKIK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	120/482 (25%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	122/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920