DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313b1 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	129/491 - (26%)
Similarity:	239/491 - (48%)	Gaps:	35/491 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQM-MNPETFLQYMDGLSRQF-KAPFISWMG 73
            ||:|:|.....|||  :|..:..||.|.||:|...|| .||...|..:.....|: |..|:.|:|
  Fly    14 LLVAYLELSTFRRR--RVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFVFWIG 76

  Fly    74 TSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHKHRRLINPAFGRQILS 138
            |...:.:.....:|.||:|.....|.|.|:.....:|.||.||:..:|||||::|.|||...||.
  Fly    77 TYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQ 141

  Fly   139 NFLPIFNAEAEVLLQKLELEGVQHGKRL-EIYQILKKIVLEAACQTTMGKKMNFQHDGSLCIFKA 202
            :|..:.|..:...::  .|:.|..|..: :..:....:.|:..|.|.||..:|...:.|..|.:|
  Fly   142 DFHEVMNENSTKFIK--HLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQA 204

  Fly   203 YNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLLEPIV-----SVVAANSNP 262
            :..:......|...|....:|:||.:..:....:.:..|..|..:::...:     ..|:.|:..
  Fly   205 FKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGD 269

  Fly   263 DQQRSEMEMRGKSKAIFIEQVREHVERGQ-LSWQDVRDEANVTIAATFETTSTALYFTILCLAMH 326
            :..|.:|        .|::.:......|: |:.:::.:|.:..:....:||::.:.|.:..|:.|
  Fly   270 EFTRKKM--------AFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRH 326

  Fly   327 PCYQEKLHK---ELVTELPPSGDINLEQLQRLEYTEMVINEAMRLFAPVPMVLRSADQDIQLKRG 388
            ...|.||.|   |::.......|...:::.:::|.::.|.||.|::..||.:.|..::|..:
  Fly   327 QDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVI--- 388

  Fly   389 DGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFVPFTKGLRMCIGYR 453
            ||: |:|:||.:.:.:..:..:|:|:.. ...:.|: .|.|:.|  ..|.:|||:.|.|.|||.:
  Fly   389 DGD-LVPKGTTLNLGLVMLGYNEKVFKD-PHKFRPE-RFELEKP--GPFEYVPFSAGPRNCIGQK 448

  Fly   454 YAQMLMKLLLARIFRSYRISTEARLEELLVK-GNIS 488
            :|.:.:|.::::|.|::.:.  ..|:||:.| |.||
  Fly   449 FALLEIKTVVSKIIRNFEVL--PALDELVSKDGYIS 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	114/452 (25%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	114/453 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.970