DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313b1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	550	Identity:	141/550 - (25%)
Similarity:	241/550 - (43%)	Gaps:	103/550 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILSGWLLLAWLYFLWSRRRYYKVAWQLR----------GPIG--WPLIGMGLQMMNPETFLQYMD 58
            ::|..|||...:|.....|.:|:....|          .|.|  |.|..|.:.:.|.:
Mouse    23 VVSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMYLPNEK------- 80

  Fly    59 GLSRQFKA------PFISWMGTSC-FLYINDPHSVEQILNSTHCTNKGD--FYRFMSSAIGDGLF 114
            ||..:.|.      ..::|:|... .|.:..|..::.:|.::......|  ||.|:...:||||.
Mouse    81 GLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLL 145

  Fly   115 TSSSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGK-----------RLEI 168
            .|...:|.:||||:.|||...||..::.|||          :...:.|.|           ..::
Mouse   146 ISKGNKWSRHRRLLTPAFHFDILKPYMKIFN----------QCTNIMHAKWRRHLAEGSVTSFDM 200

  Fly   169 YQILKKIVLEAACQTTMGKKMNFQHDGSLCIFKAYNG---------------LTEVCVKRMLSPW 218
            ::.:..:.|::.               ..|:| :||.               |:.:.|:|.....
Mouse   201 FEHISLMTLDSL---------------QKCVF-SYNSDCQERMSDYISSIIELSALVVRRQYRLH 249

  Fly   219 LYPDLIYRRSGLFRLQQKVVGILFGFIEQLLEPIVSVVAANSNPDQQRSEMEMRGK-SKAI-FIE 281
            .|.|.:|..:...|..::....:..|..::::.....:.      ||.:|..::.| .|.: ||:
Mouse   250 HYLDFMYYLTADGRRFRQACDTVHNFTTEVIQERRQALR------QQGAEAWLKAKQGKTLDFID 308

  Fly   282 --QVREHVERGQLSWQDVRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLHKEL--VTELP 342
              .:.:..|..:||.:|:|.||:..:....:|||:.|.:.:..||.:|.||||..:|:  |.:..
Mouse   309 VLLLAKDEEGKELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGR 373

  Fly   343 PSGDINLEQLQRLEYTEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNM 407
            ...:::.:.|.:|.:|.|.|.|::|.|.||.::.|...:||:|.  ||. :||:|....:.||..
Mouse   374 ELEELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLP--DGR-VIPKGIICLVSIYGT 435

  Fly   408 QRDERVWGPLSRTYNPDAHFGLDSP-QRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYR 471
            ..:..|| |.|:.||| ..|..|:| ||...|||||:.|.|.|||..:|...|::::|.....:|
Mouse   436 HHNPIVW-PDSKVYNP-YRFDPDTPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFR 498

  Fly   472 ISTE-----ARLEELLVKGNISLKLKDYPL 496
            :|.:     .|..||:::....|.|...||
Mouse   499 LSVDRTHKVRRKPELILRTENGLWLNVEPL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	126/494 (26%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	129/498 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920