DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4d1

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	135/514 - (26%)
Similarity:	255/514 - (49%)	Gaps:	37/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASIILSGWLLLAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQMMNP------ETFLQYMDG 59
            :|||.:..| |||..|.|    :|...:...:.||...||:|.|...:..      :...::|:.
  Fly     8 ILASALFVG-LLLYHLKF----KRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMET 67

  Fly    60 LSRQ--FKAPFISWMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWH 122
            .|:.  .|.    |:|....:.:.:|..||.:|.:....:|...|:.:...:.:||..|...:||
  Fly    68 YSKDQVLKV----WLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWH 128

  Fly   123 KHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHG-KRLEIYQILKKIVLEAACQTTMG 186
            |.|::|.|||..:||..|:.:|...:..||:.:|.:.::|| ....:|..:....::..|:|.||
  Fly   129 KRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMG 193

  Fly   187 KKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLL-E 250
            ..:|.|.:......:|...::.|..|||.:.....||.|..:.|.|.::|.:.:|..|.|::: :
  Fly   194 VSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQ 258

  Fly   251 PIVSVVAANSNPDQQRSEMEMRGKSKAIFIE-QVREHVERGQLSWQDVRDEANVTIAATFETTST 314
            ....::...|:.:....:.::..|.|..|:: .::..|:...||..|:|:|.:..:....:|||:
  Fly   259 RREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSS 323

  Fly   315 ALYFTILCLAMHPCYQEKLHKEL--VTELPPSGDINLEQLQRLEYTEMVINEAMRLFAPVPMVLR 377
            ||.|....:|.||..|:|..:|:  |.....|..::.|.|.:|.|.::.:.|.:|::..||::.|
  Fly   324 ALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGR 388

  Fly   378 SADQDIQLKRGDGEFLIPRGTQIGID-IYNMQRDERVWGPLSRTYNPDAHFGLDSPQR-HAFAFV 440
            ...:|.::   :|: |||.||.|||. :|..:|:|....|  ..:.|:....:.:.:: :.:|::
  Fly   389 KVLEDCEI---NGK-LIPAGTNIGISPLYLGRREELFSEP--NIFKPERFDVVTTAEKLNPYAYI 447

  Fly   441 PFTKGLRMCIGYRYAQMLMKLLLARIFRSYRI-----STE--ARLEELLVKGNISLKLK 492
            ||:.|.|.|||.::|.:.:|.::|.:.|.|.:     |:|  ..:.||:::....|..|
  Fly   448 PFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	119/460 (26%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	125/482 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.970