DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313b1 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	150/521 - (28%)
Similarity:	243/521 - (46%)	Gaps:	50/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SGWLLLAWL-------YFLWSRRRYYKVAWQLR----GPI-GWPLIGMGLQMMNPETFLQYMDGL 60
            |.||||..:       |.|......::.:.:||    .|. .|....:|| :.:.|..|.|:..|
  Rat    17 SPWLLLLLVGASCLLAYILPQVYAVFENSRRLRRFPQPPTRNWLFGHLGL-IQSSEEGLLYIQSL 80

  Fly    61 SRQFKAPFISWMGT-SCFLYINDPHSVEQILNSTHCTNKGD--FYRFMSSAIGDGLFTSSSPRWH 122
            ||.|:.....|:|. ...:.|..|..::.::.:.......|  ||||:...:||||..|:..:|.
  Rat    81 SRTFRDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGLLLSTGDKWS 145

  Fly   123 KHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMGK 187
            :||.::.|||...||..::.|||....::..|.:....|...||::::.:..:.|::..:.....
  Rat   146 RHRHMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQKCVFSF 210

  Fly   188 KMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYR--RSGL-FRLQQKVVGILFGFIEQLL 249
            ..|.|...|..| .|...|:.:..:|..|..||.||.|.  |.|: ||   |...::..|.:.::
  Rat   211 DSNCQEKPSEYI-TAILELSALVARRHQSLLLYVDLFYHLTRDGMRFR---KACRLVHDFTDAVI 271

  Fly   250 EPIVSVVAANSNPDQQRSE-MEMRGKSKAI-FIEQV----REHVERGQLSWQDVRDEANVTIAAT 308
            ..     ...:.|||...: ::.:.|:|.: ||:.:    .||.|  .||.:|:|.||:..:...
  Rat   272 RE-----RRRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGE--ALSDEDIRAEADTFMFGG 329

  Fly   309 FETTSTALYFTILCLAMHPCYQEKLH---KELVTELPPSGDINLEQLQRLEYTEMVINEAMRLFA 370
            .:||::.|.:.:..||.||.|||:..   :||:.:..|. :|..:.|.:|.:..|.|.|::||..
  Rat   330 HDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPE-EIEWDDLAQLPFLTMCIKESLRLHP 393

  Fly   371 PVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQ-R 434
            |...:.|...|||.|.  ||. :||:|....|.|:....:..|| |....||| ..|..|:.: |
  Rat   394 PATAISRCCTQDIMLP--DGR-VIPKGVICRISIFGTHHNPAVW-PDPEVYNP-FRFDADNGEGR 453

  Fly   435 HAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTE----ARLEELLVKGNISLKLKDYP 495
            ...||:||:.|.|.|||..:|...||:.||.....:|:..:    .|..||:::....|.|:..|
  Rat   454 SPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEP 518

  Fly   496 L 496
            |
  Rat   519 L 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	135/461 (29%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	133/457 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920